Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2006; 52(6): 79-84

Agefeatures of signaling lipids content in rat liver and brain

Loay Khaled Mohammad Hassouneh, Y. Semenova, O. Krasilnikova, N. Babenko

    Karazin National University, Kharkiv, Ukraine;Institute of Biology, Kharkiv, Ukraine



Abstract

The effect of age on signaling lipids contents in rat liver and different brain regions (hippocampus, neocortex) were stud- ied. The contents of free fatty acids in the brain, diacylglycerol in liver and ceramide in all tissues studied have been found to increase with age. Age-dependent accumulation of neutral and sphingolipids evokes the violation of cell sensitivity to extra- cellular signals.

Full text: (PDF, in Ukrainian)

References

  1. Старение мозга / Под ред. aкад. УССР Фролькиса В.В. – Л.: Наука, 1991. – 277с.
  2. Akbar M., Galderon F., Weh Z., Kim H.-Y. Docosa- hexaenoic acid: A positive modulator of Akt signaling in neuronal survival // PNAS. – 2005. – 102, № 31. – P. 10858–10863.
  3. Ayasolla K., Khan M., Singh A.K., Singh J. Inflammatory mediator and в-amyloid (25-35)-induced ceramide gen-eration and iNOS expression are inhibited by vitamin E //Free Rad. Biol. and Med. – 2004. – 37. – P. 325–338.
  4. Babenko N., Shachova E. Effects of Chamomilla recutita flavonoids on age-related liver sphingolipid turnover in rats // Exp. Gerontol. – 2005. – 41. – P. 32–39.
  5. Bell R.M., Burns D.J. Lipids activation of protein kinase C // J. Biol. Chem. – 1991. – 266. – P. 4661 – 4664.
  6. Berridge M.J. Intracellular signaling through inositol trisphosphate and diacylglycerol // Biol. Chem. Hoppe Seyler. – 1986. – 367, №6. – P. 447–456.
  7. Bligh E.G., Dyer W.J. A rapid method of total lipid extraction and purification // Canad. J. Biochem. Physiol. – 1959. – 37, №8. – P. 911–917.
  8. Brann A.B., Tcherpakov M., Williams I.M. et al. Nerve growth factor-induced p75-mediated death of cultured hippocampal neurons is age-dependent and transduced through ceramide generated by neutral sphingomyelinase// J. Biol. Chem. – 2002. – 277, №12. – P. 9812–9818.
  9. 9. Cunha R.A., Constantino M.D., Fonseca E., Ribeiro J.A. Age-dependent decrease in adenosine A1 receptor binding sites in the rat brain. Effect of cis unsaturated free fatty acids // Eur. J. Biochem. – 2001. – 268, №10. – P. 2939–2947.
  10. 10. Ebinu J.O., Bottorff D.A., Chan E.Y. et al. RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs // Science. – 1998. – 280. – P.1082–1086.
  11. Fulop T., Larbi A., Douziech N. et al. Signal transduc- tion and functional changes in neutrophils with aging // Aging Cell. – 2004. – 3, №4. – P. 217–226.
  12. Ghosh S., Xie W.Q., Quest A.F.G. et al. The cysteine-rich region of Raf-1 contains zinc, translocates to liposomes and is adjacent to a segment that binds GTP-ras // J. Biol. Chem. – 1994. – 269. – P. 10000–10007.
  13. Giusto N.M., Salvador G.A., Castagnet P.I. et al. Age- associated changes in central nervous system glycerolipid composition and metabolism // Neurochem. Res. – 2002. – 27, №11. – P. 1513–1523.
  14. Kavok N.S., Krasilnikova O.A., Babenko N.A. Increase in diacylglycerol production by liver and liver cell nuclei at old age // Exp. Gerontol. – 2003. – 38. – P. 441–447.
  15. Koudinova N.V., Koudinov A.R., Yavin E. Alzheimer’s Abeta 1-40 peptide modulates lipid synthesis in neu- ronal cultures and intact rat fetal brain under normoxic and oxidative stress conditions // Neurochem. Res. –2000. – 25. – P. 653–660.
  16. Krasilnikova O.A., Kavok N.S., Babenko N.A. Drug- induced and postnatal hypothyroidism impairs the accu- mulation of diacylglycerol in liver and liver cell plasma membranes // BMC Physiology. – 2002. – 2. – P. 12.
  17. Levi deStein M., Medina J.N., DeRobertis E.D. In vivo and in vitro modulation of central type of benzodiaz- epine receptors by phosphatidylserine // Mol. Brain Res. – 1989. – 5. – P. 9–15.
  18. Lightle S.A., Oakley J.I., Nikolova-Karakashian M.N. Activation of sphingolipid turnover and chronic gen-eration of ceramide and sphingosine in liver during ag- ing // Mech. Ageing Dev. – 2000. – 120. – P. 111–125.
  19. 19. March J.B., Weinstein D.B. Simple charring method for determination of lipids // J. Lipid Res. – 1966. – 7, №4. – P. 574–580.
  20. 20. Martin S.F. Navarro F., Torthoffer N. et al. Neutral mag- nesium-dependent sphingomyelinase from liver plasma membrane: purification and inhibition by ubiquinol // J.Bioenerg. Biomembr. – 2001. – 33. – P. 143–153.
  21. Meyer S.G.E., de Groot H. [14C]serine from phospha-tidylserine labels ceramide and sphingomyelin in L 929cells: evidence for a new metabolic relationship be-tween glycerophospholipids and sphingolipids // Arch.Biochem. Biophys. – 2003. – 410. – P. 107–111.
  22. Nicolle M.M., Colombo P.J., Gallagher M., McKinney M. Metabotropic glutamate receptor-mediated hippoc- ampal phosphoinositides turnover is blunted in spa-tial learning-impaired aged rats // J. Neurosci. – 1999. –19, №21. – P. 9604–9610.
  23. Pushkareva M., Obeid L.M., Hannun Y.A. Ceramide: an endogenous regulator of apoptosis and growth suppres- sion // J. Immunol. Today. – 1995. – 60. – P. 643–665.
  24. Schmitz-Pfeiffer C. Protein kinase C and lipid-induced insulin resistance in skeletal muscle // Ann. Acad. N.Y. Sci. – 2002. – 967. – P. 146–157.
  25. Wu D., Marko M., Claycombe K., Paulson K. E., Meydani S.N. Ceramide-induced and age-associated increase in macrophage COX-2 expression is mediates through up-regulation of NF-kB activity // J. Biol.Chem. – 2003. – 278. – P. 10983–10992.
  26. Wu D., Meydani S.N. Mechanism of age-associated up-regulation in macrophage PGE2 synthesis // Brain Behav. Immun. – 2004. – 18. – P. 487–494.
© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.