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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2011; 57(2): 3-13


Interrelation between cardiac pump function disturbances and cardiac contractility after a-adrenergichyperstimulation in rats

M.O. Kuzmenko, V.B. Pavlyuchenko, L.V. TumanovS.ka, V.E. Dosenko, O.O. Moybenko

    Ін-т фізіології ім. О.О. Богомольця НАН України, Київ


Abstract

The complex of structural and functional changes of myocar­dium was investigated in experiments with rats with chronic P-adrenergic activation for 1 month. We observed substantial attenuation of myocardial pump function, particularly reduction of stroke volume by 38,50% (P<0,01), cardiac output by 42,38% (P<0,01), and ejection fraction by 35,61% (P<0,01). Furthermore, 2-fold increase of end-diastolic left ventricular pressure (P<0,01) and rise of active relaxation constant Tau by 12,91% (P<0,05) were observed. This indi­cates on an impaired diastolic function of the heart that is associated with accumulation of connective tissue elements in myocardium and increase of its end-diastolic stiffness that finally leads to cardiac pump function disturbances. Surpris­ingly, myocardial contractility was considerably augmented not only after the treatment with P-adrenergic agonist but also on the 26th day after drug cessation. This phenomenon is asso­ciated with elevation of dP/dt by 49,9% (P<0,01), 2,5-fold increase of end-systolic elastance (P<0,01) as well as maximal myocardial elastance by 42,53% (P<0,05). It can be explained by compensatory influence of increased contractility that nevertheless failed to maintain adequate cardiac pump func­tion and furthermore it may result in depletion of cardiac energy resource.

Keywords: ?-адренорецепторы, сократимость,насосная функция, сердце.

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