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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2011; 57(2): 3-13

Interrelation between cardiac pump function disturbances and cardiac contractility after beta-adrenergic hyperstimulation of the heart in rats

Kuz'menko MO, Pavliuchenko VB, Tumanovs'ka LV, Dosenko VIe, Moĭbenko OO

    Bogomoletz Institute of physiology NAS of Ukraine, Kyiv, Ukraine


The complex of structural and functional changes of myocar­dium was investigated in experiments with rats with chronic P-adrenergic activation for 1 month. We observed substantial attenuation of myocardial pump function, particularly reduction of stroke volume by 38,50% (P<0,01), cardiac output by 42,38% (P<0,01), and ejection fraction by 35,61% (P<0,01). Furthermore, 2-fold increase of end-diastolic left ventricular pressure (P<0,01) and rise of active relaxation constant Tau by 12,91% (P<0,05) were observed. This indi­cates on an impaired diastolic function of the heart that is associated with accumulation of connective tissue elements in myocardium and increase of its end-diastolic stiffness that finally leads to cardiac pump function disturbances. Surpris­ingly, myocardial contractility was considerably augmented not only after the treatment with P-adrenergic agonist but also on the 26th day after drug cessation. This phenomenon is asso­ciated with elevation of dP/dt by 49,9% (P<0,01), 2,5-fold increase of end-systolic elastance (P<0,01) as well as maximal myocardial elastance by 42,53% (P<0,05). It can be explained by compensatory influence of increased contractility that nevertheless failed to maintain adequate cardiac pump func­tion and furthermore it may result in depletion of cardiac energy resource.

Keywords: ?-адренорецепторы, сократимость,насосная функция, сердце.


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