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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

(English title: Physiological Journal)

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2026; 72(3): 26-33

THE INFLUENCE OF THYROID HORMONES ON THE BLOOD LIPID PROFILE IN HEIFERS DEPENDING ON AGE

N. Fedak1, L. Piddubna2, O. Lesnovska3, L. Mykolaichuk3, D. Mylostyva4, A. Babchenko4, R. Mylostyvyi3

  1. 1 Institute of Agriculture of the Carpathian region of the National Academy of Agrarian Sciences, Obroshyne village, Lviv region
  2. 2 Polissia National University, Zhytomyr
  3. 3 Dnipro State Agrarian and Economic University, Dnipro
  4. 4 Dnepropetrovsk Scientific Research Institute of Forensic Expertise of the Ministry of Justice of Ukraine, Dnipro
DOI: https://doi.org/10.15407/fz72.03.026


Abstract

The secretory activity of the thyroid gland (TG) and the effects of thyroid hormones in the bodies of heifers of the V olyn beef breed were assessed according to age. Age-related changes in lipid metabolism and free fatty acids (FFA) synthesis were observed under the influence of thyroid hormones. It was established that the effects of the hormones are mediated primarily by triiodothyronine (T3), the concentration of which is associated with key parameters of lipid metabolism. In the animals, the maximum thyroxine (T4) content was observed at 8 months of age and subsequently decreased gradually by 21.8% and 45.2% at 15 and 18 months of age, respectively. The lowest T3 levels were observed at 15 months, and the highest at 18 months. Age also influenced lipid metabolism parameters. Total lipid (TL) levels at 15 and 18 months were 16.61% and 66.35% lower, respectively, compared to 8-month-old animals. Compared to 8-month-old animals, total cholesterol (TC) levels in 15- and 18-month-old animals were also lower by 14.9% and 21.1%, respectively. The influence of thyroid hormones on FFA synthesis, depending on age, was also observed. The most pronounced correlations at 8 months of age were observed between T3 levels and palmitic acid and oleic acid, as well as T4 and capric acid; in 15-month-old animals-between T3 and oleic acid and T4 and arachidonic acid; in 18-month-old animals-between T3 and palmitic acid and T4 and stearic acid. The results obtained allow the use of indicators of hormonal-metabolic relationships to assess the physiological state of animals of different ages.

Keywords: metabolism; lipid metabolism; thyroid hormones; age-related differences; fatty acids

Full text: (PDF, in Ukrainian)

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