Infusion therapy in peritonitis aims to optimize oxygen delivery to tissues and improve its utilization. These tasks are achieved through infusion therapy with crystalloid and colloid solutions, optimization of cardiac output with inotropic and vasopressor drugs, and the use of blood products. The choice of solution for infusion therapy in peritonitis is made taking into account the deficit in circulating blood volume, the response of systemic hemodynamics to infusion, the degree of organ failure, and the development of adverse reactions. Our study aimed to compare the effect of infusion solutions administered by three different routes on changes in blood electrical resistance and total blood salt content. The experiment was conducted on 42 male rabbits weighing 2,17 ± 0,39 kg, which were divided into two groups. The first group had no peritonitis, the second had peritonitis, with 21 animals in each group, of which three animals in each group did not receive infusions and served as controls. The experimental animals were injected with 10% albumin solution and saline solution (0.9% sodium chloride), followed by blood sampling and determination of blood electrical resistance and total blood salt content using an EC/TDS-616 salimeter. Peritonitis was modelled by intraperitoneal administration of a 10% fecal solution 12 h before the experiment. It was found that there were significant differences in the total salt content in the blood between groups of healthy animals that received intravenous injections of saline solution and animals with peritonitis; blood electrical resistance, and total blood salt content between groups of healthy animals with intraosseous administration of 10% albumin solution and animals with peritonitis.