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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

(English title: Physiological Journal)

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2026; 72(2): 57-64

DOES OLANZAPINE-INDUCED OBESITY CAUSE PATHOLOGICAL CHANGES IN THE ESOPHAGEAL MUCOSA OF ANIMALS?

M.А. Shchetinin1, A.А. Kotvytska1, K.V. Tikhonovych1, M.V. Bilets1, O.Y. Omelchenko1, D.O. Khmil1, K.S. Neporada1

  1. Poltava State Medical University, Ukraine
DOI: https://doi.org/10.15407/fz72.02.057


Abstract

Recent experimental and clinical studies have expanded the understanding of the mechanisms underlying metabolic and gastrointestinal adverse effects of olanzapine, an atypical anti- psychotic widely used in the treatment of psychotic disorders and associated with the development of obesity. The present study aimed to elucidate the mechanisms of pathological changes in the esophageal mucosa of rats under conditions of administration of different doses of olanzapine. A total of 15 male rats were included and randomly assigned to experimental groups. Biochemical parameters of the esophageal mucosa were assessed, including the content of glycosaminoglycans (GAGs), free fucose, hydroxyproline, thiobarbituric acid- reactive substances (TBARS), oxidatively modified proteins (OMP), as well as the activity of catalase, proteinases, and their inhibitors. It was found that endogastric administration of olan- zapine at doses of 4 mg/kg and 8 mg/kg body weight resulted in the development of visceral obesity, as evidenced by a signifi- cant increase in body mass index, Lee index, and visceral fat mass in experimental animals compared with intact controls. Analysis of changes in the esophageal mucosa revealed that olanzapine-induced visceral obesity led to the activation of free radical processes, as indicated by a significant increase in the levels of OMP and TBARS compared to intact animals. Ad- ditionally, a significant increase in GAGs, hydroxyproline, and free fucose content in the esophageal mucosa of experimental rats was observed compared with the control group, indicat- ing enhanced catabolism of glycoproteins and proteoglycans in the connective tissue of the rat esophagus. Thus, the use of atypical antipsychotics, particularly olanzapine, contributes to the development of oxidative stress, activation of proteolysis, and intensified degradation of fucoproteins, proteoglycans, and collagen proteins of the esophagus.

Keywords: olanzapine, obesity, esophagus, oxidative stress, fucose, hydroxyproline

Full text: (PDF, in Ukrainian)

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