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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

(English title: Physiological Journal)

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2025; 71(5): 98-105

THE INFLUENCE OF MYOKINES ON THE CARDIOVASCULAR SYSTEM

S.N. Vadzyuk1, P.S. Tabas1, L.I. Gorban1, I.Ya. Papinko1, I.G. Bidzyura2

  1. I. Horbachevsky Ternopil National Medical University, Ukraine
  2. Municipal Institution of Higher Education «Volyn Medical Institute» of the Volyn Oblast Council, Lutsk, Ukraine
DOI: https://doi.org/10.15407/fz71.05.098


Abstract

Myokines (such as irisin, myonectin, myostatin, and brain- derived neurotrophic factor) are secreted by skeletal muscles in response to exercise and significantly affect the cardiovascular system. Irisin prevents the development and progression of heart failure, ischemic heart disease, sarcopenia, and other diseases by reducing inflammation, improving antioxidant defense, preventing cardiomyocyte apoptosis, and stimulating angiogenesis. Myonectin enhances protective processes in the heart during ischemic injury by reducing apoptosis and inflam- matory reactions in the myocardium. Conversely, myostatin is associated with the development of heart failure, athero- sclerosis, and vascular aging; its overexpression negatively affects the state of the cardiovascular system. Brain-derived neurotrophic factor is involved in the regulation of cardiac function and is a promising biomarker for predicting the course of cardiac activity. Regular physical activity, by stimulating the secretion of cardioprotective myokines, reduces the risk of developing ischemic heart disease, heart failure, and associated metabolic disorders. Determining myokine levels in peripheral blood has the potential for early diagnosis and risk assessment of cardiovascular events, opening up new opportunities for personalized therapy.

Keywords: myokines, cardiovascular system, hypertension, ischemic heart disease, endocrine system, sarcopenia, physical activity

Full text: (PDF, in Ukrainian)

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