Menstrual disorders are increasingly being observed in women recovering from COVID-19. Mechanisms include neuroendocrine suppression, endothelial dysfunction, and systemic inflammation, which may transiently impair hypothalamic-pituitary-ovarian axis activity and endometrial perfusion. The aim of our study was to substantiate and evaluate the effectiveness of a pathogenetically targeted personalized rehabilitation program for restoring menstrual function in women after COVID-19. Women of reproductive age (n = 82) with menstrual disorders that developed within six months after COVID-19 participated in the study. The personalized protocol included hormonal correction (dopamine agonists, levothyroxine, estrogen- progestagen therapy according to indications), metabolic and antioxidant support (vitamin D 3 , N-3 PUF As, folic acid and vitamin B 12 , magnesium-B 6 complex), as well as chronobiotic and psychological regulation (melatonin, cognitive-behavioral therapy, sleep hygiene). The primary endpoint was the restoration of a regular cycle (21-35 days); secondary endpoints were hormonal normalization and improvement in SF-36 quality of life. Regular menstrual cycles were restored in 90.2% of women within 3.9 ± 1.6 months. Hormonal normalization (euthyroid state, normoprolactinemia, physiological level of sex hormones) was achieved in 80.5%. Total Short Form-36 Health Survey questionnaire scores (SF-36) increased from 58.4 ± 12.7 to 83.8 ± 8.9. Side effects were mild and transient (9.8%). Personalized rehabilitation, including hormonal, metabolic, antioxidant, and psychoneuroendocrine correction, significantly improved reproductive recovery after COVID-19. Vitamin and micronutrient supplementation, particularly folic acid, magnesium, melatonin, and vitamin D 3 is pathogenetically justified and promotes faster normalization of menstrual and hormonal function in women of reproductive age.