Recent years have been marked by a significant increase in the number of patients with metabolic syndrome and a deterioration in the repair processes of damaged tissues with an increase in the number of surgical interventions, which requires the study of the pathophysiological mechanisms of these disorders. One of the links in the mechanism of impaired wound healing may be changes in the hemomicrocirculation of skin vessels in the presence of metabolic syndrome. The aim of the work is to study the features of peripheral hemomicrocirculation of skin microvessels in women with signs of metabolic syndrome. The work is based on the results of the examination of 30 women (the main group) who consulted about cosmetic skin defects aged 40 to 55 years and had signs of metabolic syndrome. The control group included 30 practically healthy women aged 39 to 54 years. It was found that in 66.7% of people with signs of metabolic syndrome, the parallelism of the capillary loops was disturbed, the number of functioning capillary loops in them was significantly lower. Avascular fields were detected in 57.8% of patients in the main group. A decrease in the length of the arteriolar knee of vascular loops was detected in 53.3% of the examined, and in the control group only in 23.3% of cases. The length of their venular knee was increased in 66.7% of the examined people in the main group (in the control group only in 23.3%), which indicates a compensatory increase in the total volume of the venular link of the hemomicrocirculatory bed. Metabolic syndrome is characterized by unevenness of the caliber of the venular knee of the vascular loops of the nail bed, which is a sign of overload of the venular link of the peripheral hemomicrocirculation. It is concluded that metabolic syndrome is characterized by disorders of peripheral hemomicrocirculation at the functional and structural levels.