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Fiziologichnyi Zhurnal - <a id="lj1_ret_bk_to_jl0_href_id" href="?list0=11">Fiziol. Zh. 2009;</a> <a id="lj1_ret_bk_to_jl0_href_id" href="?list1=55">55(4):</a> 109-115
Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2009; 55(4): 109-115


The effect of preadaptation on the acutehypobaric stress and physiological bone tissue regeneration

V.A. Berezovskii, I.G. Litovka, A.S. Kostyuchenko

    Ін-т фізіології ім. О.О. Богомольця НАН України, Київ


Abstract

In experiments on rats we investigated the resistance to the barochamber testing (12000 u.s.l. velositi 80 m/s) before and after training for 14 and 28 days in the normobaric gas mixture(N2 + O2, Po2 = 100+-10 mm of Hg). It was shown that after preadaptation the resistance to acute hypobaric hypoxia in­creased 1,7-1,8 times. Alimentary deprivation (40%) does not essentially affect the resistance to hypoxia. Biochemical markers show that normobaric low-dosed hypoxic preadapta­tion (14 days) activates the physiological regeneration pro­cess, promote the increase in concentrations of leptin, parathyreoid and growth hormones. Alimentary deprivation decreased an alkaline phosphatase activity and concentration of growth hormone. We suggest that normobaric hypoxic pre­adaptation but not alimentary limitation has definite positive influence on the bone tissue state.

References

  1. Березовский В.А., Дейнега В.Г. Физиологические механизмы саногенных эффектов горного климата. -К.: Наук. думка, 1988. - 222 с.
  2. Ван Лир Э., Стикней К. Гипоксия / Пер. с англ. -М.: Медицина, 1967.- 367 с.
  3. Гипоксия. Адаптация, патогенез, клиника / Под общ. ред. Ю.Л. Шевченко. - СПб.: ООО «ЭЛБИ-СПб», 2000. - 384 с.
  4. Кляцкин С.А., Лифшиц Р.И. Определение глико-заминогликанов орциновым методом в крови больных // Лаб. дело. - 1989. - № 10. - С. 51-53.
  5. Колчинская А.З. Использование ступенчатой адаптации к гипоксии в медицине // Вестн. Рос. АМН. - 1997.-№5.-С.12-19.
  6. Литовка И.Г. Дозированная гипоксия как фактор коррекции остеопении бездействия // Косм. наука і технологія. - 2002. - 8, №4. - С.81-85.
  7. Нагорный А.В. Старение и продление жизни. - М.: Сов. наука, 1950. - 214 с.
  8. СтрелковР.Б.,ЧижовА.Я.Прерывистаянормобарическая гипоксия в профилактике, лечении и реабилитации. -Екатеринбург: Урал. рабочий, 2001. - 400 с.
  9. 9. Bado A., Levasseur S., Attoub S., Kermorgant S. The stomach is a source of leptin//Nature.- 1994. - 394, №6695. - P. 790-793.
  10. 10. Fern6ndez-Tresguerres H-G. I., Alobera-Gracia M. A., Mariano C. P., Jerez L. B. Physiological bases of bone regeneration II. The remodeling process//Med. Oral. Patol. Oral. Cir. Bucal. - 2006, №1. - P.151-157.
  11. Kalu D. N., Hardin R. R., Cockerham R., Yu B. P., Norling B. Lifelong food restriction prevents senile osteoporosis and hyperparathyroidism in F344 rats// Mech. Ageing Dev. - 1984. - 26. - P.103-112.
  12. Lane M.A., Reznick A.Z., Tilmont E.M. Aging and food restriction alter some indices of bone metabolism in male rhesus monkeys (Macaca mulatta)//J. Nutrit. -1995. - 125, №6. - P. 1600-1610.
  13. MeiЯner U., Hflnisch C., Ustreicher I., Knerr I. Dif­ferential Regulation of Leptin Synthesis in Rats Dur­ing Short-term Hypoxia and Short-term Carbon Monoxide Inhalation//Europ. J.Endocrinol. -2005. -153, №3. - P. 455-461.
  14. McCay CM. Reprint size//Science. - 1941. - 94, №2444. - 415 p.
  15. Netzer N.C, Chytra R., Kьpper T. Low intense physi­cal exercise in normobaric hypoxia leads to more weight loss in obese people than low intense physical exercise in normobaric sham hypoxia//Sleep Breath. - 2008. - 12. -P.129-134.
  16. Ohlsson C, Bengtsson B., Isaksson Olle G. Growth Hormone and Bone// Endocrine Rev. - 1998. - 19, №1. -P. 55-79.
  17. Reeve J. PTH: a future role in management of os-teoporosis?//J.Bone Miner. Res. - 1996. - 11, №4. -P.440-445.
  18. Takeda S. Central control of bone remodeling//Biochem. and Biophys. Res. Comm. - 2005. - 328, №4. - P. 697-699.
  19. 19. Talbott S. M., Cifuentes M., Dunn M. G. , Shapses S.A. Energy restriction reduces bone density and bio-mechanical properties in aged female rats// J. Nutrit. -2001. - 131. - P.2382-2387.
  20. 20. Weindruch R., Sohal R. S. Caloric intake and aging// New Engl. J. Med. - 1997. - 337, №6. - P. 984-986.

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