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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2009; 55(4): 109-115

The effect of preadaptation on the acutehypobaric stress and physiological bone tissue regeneration

V.A. Berezovskii, I.G. Litovka, A.S. Kostyuchenko

    Ін-т фізіології ім. О.О. Богомольця НАН України, Київ



Abstract

In experiments on rats we investigated the resistance to the barochamber testing (12000 u.s.l. velositi 80 m/s) before and after training for 14 and 28 days in the normobaric gas mixture(N2 + O2, Po2 = 100+-10 mm of Hg). It was shown that after preadaptation the resistance to acute hypobaric hypoxia in­creased 1,7-1,8 times. Alimentary deprivation (40%) does not essentially affect the resistance to hypoxia. Biochemical markers show that normobaric low-dosed hypoxic preadapta­tion (14 days) activates the physiological regeneration pro­cess, promote the increase in concentrations of leptin, parathyreoid and growth hormones. Alimentary deprivation decreased an alkaline phosphatase activity and concentration of growth hormone. We suggest that normobaric hypoxic pre­adaptation but not alimentary limitation has definite positive influence on the bone tissue state.

Full text: (PDF, in Ukrainian)

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