INFLUENCE OF CITALOPRAM, A SELECTIVE SEROTONIN REUPTAKE INHIBITOR, ON CIRCADIAN RHYTMS OF EXCRETORY FUNCTION OF KIDNEYS
I.G. Kushnir, G.I. Kokoshchuk
Chernivtsi National University named after Ju. Fedcovich, Ukraine
Abstract
In experiments on the white rats it was established that the citalopram in dose 5 mg/kg significantly affects the circadian rhytms of excretory function of kidneys, especially at night. We conclude that serotonin, which content is increased by citalopram, may serve as a neurotransmitter in circadian thytms regulation.
Keywords:
circasian rhytm,white rats, citalopram, setotonin
References
- Wayne AM, Voznesenskaya TG, Golubev VL, Dyukova GM Depression in neurological practice. M .: IIA, 2002. 155p.
- Ryabov SI., Natochin YV, Bodnarenko BB Diagnosis of kidney diseases. L .: Medicine, 1979. 255 p.
- Cagampang F.R., Inouye S.T. Diurnal and circadian changes of serotonin in the suprachiasmatic nuclei: regulation by light and an endogenous pacemaker . Brain Res. 1994. 639, N 1. P. 175-179.
- Duncan M.J., V.A. Davis. Cyclic AMP meditates circadian phase shifts induced by microinjection of serotonergic drugs in the hamster dorsal raphe nucleus . Ibid. 2005. 1058, N 1-2. P. 10-16.
- Horikawa Kazumasa, Shibata Shigenobu. Phase-resetting responce to (+)8-OH-DPTA, a serotonin 1 A. 7 receptor agonist, in the mouse in vivo . Neurosci. Lett. 2004. 368, N 2. P. 130-134.
- Hoyer D., Clarke D.E., Fothard J.R., Hartig P.R. et al. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin) . Pharmacol. Rev. 1994. 46. P. 157-203.
- Isbister G.K., Bowe S.J., Dawson A., Whyte I.M. Relative toxicity of selective serotonin reuptake inhibitors (SSRIs) in overdose . J. Clin. Toxicol. 2004. 42, N 3 P. 277-285.
- Kalsbeek A., Palm I.F., La Fleur S.E. et al. SCN outputs and the hypothalamic balance of life . Biol. Rhytms. 2006. 21, N 6. P. 458-469.
- 9. Leander P., Vrang N., Moller M. Neuronal projections from the mesencephalic raphe nucleus and the deep pineal gland of the golden hamster (Mesocricetus auratus). J. Comp. Neurol. 1998. 399, N 1. P. 73-93.
- 10. Mintz E.M., Gillespie C.F., Marvel C.L. et al. Serotonergic regulation of circadian rhytms in Syrian hamsters . Neuroscience. 1997. 79, Issue. P. 563-569.
- Morgan W.W., Pfeil K.A., Reiter R.J, Gonzales E. Comparison of changes in tryptophan and serotonin in regions of the hamster and the rat brain over a twenty-four hour period . Brain Res. 1976. 117, N 1. P. 77-84.
- Morin L.P., Meyer-Bernstein E.L. The ascending serotonerging system in the hamster: comparison with projections of the dorsal and median raphe nuclei . Neuroscience. 1999. 91, N 1. P. 81-105.
- Mullins U.L., Gianutsos G., Eison A.S. Effects of antidepressants on 5-HT receptors regulation in the rat hypothalamus . Neuropsychopharmacology. 1999, 21, N 3. P 352-367.
- Phillips K. Serotonin’s circadian rhytm . J. Exp. Biol. 2004. 207.
- Semba J., Toru M., Mataga N. Twenty-four hour rhythms of norepinephrine and serotonin in nucleus suprachias-maticus, raphe nuclei, and locus coeruleus in the rat . Sleep. 1984. 7, N 3. P. 211-218.
- Wildt M., E.M. Goergen, J.L. Benton, D.C. Sandeman and B.S. Beltz. Regulation of serotonin levels by multiple light-entrainable endogenous rhytms . J. Exp. Biol. 2004. 207. P. 3765-3774.
|