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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2009; 55(3): 125-127


Influence of citalopram, a selective serotonin reuptakeinhibitor, on circadian rhytms of excretory function of kidneys

I.G. Kushnir, G.I. KokoshchuK.

    Chernivtsi National University named afterJu. Fedcovich


Abstract

In experiments on the white rats it was established that the citalopram in dose 5 mg/kg significantly affects the circadian rhytms of excretory function of kidneys, especially at night. We conclude that serotonin, which content is increased by citalopram, may serve as a neurotransmitter in circadian thytms regulation.

References

  1. Вейн A.M., Вознесенская Т.Г., Голубев В.Л., Дюкова Г.М. Депрессия в неврологической практике. - М.: ИИА, 2002. - 155с.
  2. Рябов СИ., Наточин Ю.В., Боднаренко Б.Б. Диагностика болезней почек. -Л.: Медицина, 1979. -255 с.
  3. Cagampang F.R., Inouye S.T. Diurnal and circadian changes of serotonin in the suprachiasmatic nuclei: regulation by light and an endogenous pacemaker // Brain Res. - 1994. - 639, №1. - P. 175-179.
  4. Duncan M.J., V.A. Davis. Cyclic AMP meditates cir­cadian phase shifts induced by microinjection of sero­tonergic drugs in the hamster dorsal raphe nucleus // Ibid. - 2005. - 1058, - № 1-2. - P. 10-16.
  5. Horikawa Kazumasa, Shibata Shigenobu. Phase-reset­ting responce to (+)8-OH-DPTA, a serotonin 1 A/7 receptor agonist, in the mouse in vivo // Neurosci. Lett. -2004. - 368, №2. - P. 130-134.
  6. Hoyer D., Clarke D.E., Fothard J.R., Hartig P.R. et al. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin) // Pharmacol. Rev. - 1994. - 46. - P. 157-203.
  7. Isbister G.K., Bowe S.J., Dawson A., Whyte I.M. Relative toxicity of selective serotonin reuptake inhibi­tors (SSRIs) in overdose // J. Clin. Toxicol. - 2004. -42, №3 - P. 277-285.
  8. Kalsbeek A., Palm I.F., La Fleur S.E. et al. SCN out­puts and the hypothalamic balance of life // Biol. Rhytms. -2006. - 21, №6. - P. 458-469.
  9. 9. Leander P., Vrang N., Moller M. Neuronal projections from the mesencephalic raphe nucleus and the deep pi­neal gland of the golden hamster (Mesocricetus auratus)// J. Comp. Neurol. - 1998. - 399, №1. - P. 73-93.
  10. 10. Mintz E.M., Gillespie C.F., Marvel C.L. et al. Seroton­ergic regulation of circadian rhytms in Syrian hamsters // Neuroscience. - 1997. - 79, Issue. - P. 563-569.
  11. Morgan W.W., Pfeil K.A., Reiter R.J, Gonzales E. Comparison of changes in tryptophan and serotonin in regions of the hamster and the rat brain over a twenty-four hour period // Brain Res. - 1976. - 117, №1. -P. 77-84.
  12. Morin L.P., Meyer-Bernstein E.L. The ascending serotonerging system in the hamster: comparison with projections of the dorsal and median raphe nuclei // Neuroscience. - 1999. - 91, №1. -P. 81-105.
  13. Mullins U.L., Gianutsos G., Eison A.S. Effects of anti­depressants on 5-HT receptors regulation in the rat hypothalamus // Neuropsychopharmacology. - 1999, 21, №3. - P 352-367.
  14. Phillips K. Serotonin’s circadian rhytm // J. Exp. Biol. -2004. - 207.
  15. Semba J., Toru M., Mataga N. Twenty-four hour rhythms of norepinephrine and serotonin in nucleus suprachias-maticus, raphe nuclei, and locus coeruleus in the rat // Sleep. - 1984. - 7, №3. - P. 211-218.
  16. Wildt M., E.M. Goergen, J.L. Benton, D.C. Sandeman and B.S. Beltz. Regulation of serotonin levels by mul­tiple light-entrainable endogenous rhytms // J. Exp. Biol. -2004. - 207. - P. 3765-3774.

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