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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2009; 55(3): 100-108


Zh.A. Kruchenko

    O.O. Bogomoletz Institute of Physiology NationalAcademy Sciences of Ukraine, Kyiv, Ukraine


The impulse activity of prefrontal cortex neurons of hyperten­sive (SHR line) rats during realization of the food instrumental conditioned reflex in the control and under the stress induced by strong sound irritation as well as the mechanisms of the stress correction by D2-receptors blockade with sulpyride were stud­ied. A biphasic-type of prefrontal cortex neuronal activity in response to the prearranged signal which caused limb search­ing motion is revealed. This activity consisted of excitation in response to prearranged flick and inhibition which preceded and accompanied reflex motion. Cessation of impulse discharge generation under acute stress testifies the correlation between the animal emotional state and neuronal activity. D2-receptors antagonist sulpyride is shown to resume stress–injured activity by increasing food motivation and neuronal background activity and by strengthening inhibition concerned with conditioned reflex motion.

Keywords: : impulse activity, prefrontal cortex, conditioned reflex, D-2 receptors, sulpyride, rats


  1. Simonov PV The evolutionary brain. M .: Nauka, 1981. 216p.
  2. Storozhuk VM Dopaminergic modulation of neural activity in the cerebral cortex of a waking animal. К .: Naukova Dumka, 2008. 112 p.
  3. Berrigze K.C., Robinson T.E. What is the role of dopamine in reward: hedonicimpact, reward learning, or incentive salience . Brain Res.Rew 1998. 28, N 3. P.309-319.
  4. Blum K., Braverman E.R., Holder J.M. et al. Reward deficiency sindrom:a biogenetic model gor the diagno­sis and treatment of impulsive, addictive and compulsive behaviors . J.Psychoactive Drugs. 2000. 32. P. 1-112.
  5. Brozozowski T., Konturek S.J., Majka J. et al. Epidermal growth factor, poliamines and postaglandins in healing og stress-induced gastric lesions in rats . Dig. Dis. Sci. 1993. 38. P. 276-283.
  6. Dichiara G. Nucleus accumbens shel and core dopamine: differential role in behavior and addiction . Behav. Brain Res. 2002. 137, N 1-2. P. 75-114.
  7. Gerrits M.A., Petromili P., Westenberg H.G.M. et al. Decrease in basal dopamine levels in the nucleus accumbens shell during daily drugseeking behaviour in rats . Brain Res. 2002. 92 P. 141-150.
  8. Gresch P.J., Sved A.F., Zigmond M.J. et al. Local application of desipramine increases basal and stress-induced dopamine efflux in medial prefrontal cortex . Soc. Neu-rosci. Abstr. 1993. 19. P. 1828-1834.
  9. Hemsley D.R. A conditive model for schizophrenia . Behav. Brain Sci. 1991. 14. P 1-20.
  10. Joseph M.H., Datla K., Joung A.M. The interpretation of the measurement of nucleus accumbens dopamine by in vivo dialysis: the kick, the craving or the cognition? . Neurosci.Biobehav.Rev. 2003. 27, N 6. 527-541.
  11. Koob G.F., Le Moal M. Drug abuse: hedonic homeostatic dysregulation . Sciense. 1997. 278. N 5335. P. 52-58.
  12. Koob G.F., Le Moal M. Drug addiction, dysregulation of reward and allostasis . Neuropsychopharmacology. 2001. 24, N 2. P. 97-129.
  13. Langen A., Nakash R., Overstrut D.H, Jadid G. Asso­ciation between depressive behavior and absence of serotonin-dopamine interaction in the nucleus accumbens . J. Psychopharmacology. 2001. 155, N 4. P. 434-439.
  14. Meany M.Y., Brake W. Gratton A. Enviromental regulation of the development of mesolimbic dopamine systems: a neurobiological mechanism for vulnerability to drug abuse? . J. Psychoneuroendocrinol. 2002. 27, N 1-2. P. 135-141.
  15. Mingote S. , De Bruin J. P, Feenstra M.G. Noradrenaline and dopamine efflus in the prefrontal cortex in relation to appetitive classical conditioning . J. Neurosci. 2004. 24, N 10. P. 2475-2480.
  16. Orsini C, Ventura R., Lucchese F. et al. Predictable stress promotes place preference and low mesoaccum-bens dopamine response . J.Physiol. Behav. 2002. 75, N 1-2. P. 135-141.
  17. Paxinos Y., Watson C. The Kat Brainin stereotaxic coordinates. San Diego, 1998.
  18. Pezze M.A., Heidbreder C.A., Feldon J., Murphy C.A. Selective responding of nucleus accumbens core and shell dopamine to aversively conditioned contextual and discrete stimuli . J. Neurosci. 2001. 108, N 1. P. 91-102.
  19. Robbins T.W. The neuropsychological basis of addic­tive behaviour . Brain.Res. 2001. 36. N 2-3. P. 129-138.
  20. Russel V. Dopamine hypofunction possibly results from a defect in glutamate-stimulated release of dopamine in the nucleus accumbens shell of a rat model for atten­tion deficit hypoactivity disorder the spontaneously hy­pertensive rat . Neurosci. Biobehav. Rev. 2003. 27, N 7. P. 671-682.21. Schmidt K., Nolte-Zenker B., Patzer J. et al. Psychopatalogical correlates of reduced dopamine receptor sensitivity in depression, schizophrenia and opiate and alcohol dependence . J.Pharmacopsychiatry. 2001. 34, N 2. P. 66-72.
  21. Tanda C, Cabroni E., Frau R. et al. Increase of exstracellular dopamine in the prefrontal cortex: a trait of druges with antidepressant potential? . Psychophar-macolohy (Berl). 1994. 115. P. 285-288.
  22. Trith CD. Consciousness, information processing and schizophrenia . Brit. J. Psychiatry. 1979. 134. P. 225-235.
  23. Venobles P.H. Cerebral mechanisms autonomic responsiveness and attentionsn schizophrenia . Nerb. Simp. Motiv. 1984. 31. P. 47-91.
  24. Viggiano D., Vallone D., Sadile A. Dysfunctions in dopamine systems and AD. HD: evidence from animals and modeling . Natural. Plast. 2004. 11, N 2. P. 97-114.
  25. Weiner Y. The “two-headed” latent inhibition model of schizophrenia: modeling positive and negative symptoms and their treatment . Y. Hsychopharmacol. 2003, 169, N 3-4. P. 257-297.
  26. Weiss F., Markou A., Lorang M.T., Koob G.F. Basal extra­cellular dopamine levels in the nucleus accumbens are decreased during cocaine withdrawal after unlimited-ac­cess self-administration . Brain Res. 1992. 593. P. 314-318.
  27. Wise R.A. Drive, incentive, and reinforcement: the an­tecedents and concequences of motivarion . Nebr. Symp. Motiv. 2004. 50. P. 159-1955.
  28. Zahrt J., Taylor J.R., Mathew R.G. et al. Supranormal stimulation of D1 dopamine receotors in the rodent pre­frontal cortex imprais spatiat working memory perfor­mance . J. Neurosci. 1997. 17. P. 8528-8535.

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