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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2009; 55(3): 100-108

THE EFFECT OF D2-RECEPTORS BLOCKADE ON THE NORMAL AND STRESS-INDUCED ACTIVITY OF SHR RATS PREFRONTAL CORTEX NEURONS

Zh.A. Kruchenko

    O.O. Bogomoletz Institute of Physiology NationalAcademy Sciences of Ukraine, Kyiv, Ukraine



Abstract

The impulse activity of prefrontal cortex neurons of hyperten­sive (SHR line) rats during realization of the food instrumental conditioned reflex in the control and under the stress induced by strong sound irritation as well as the mechanisms of the stress correction by D2-receptors blockade with sulpyride were stud­ied. A biphasic-type of prefrontal cortex neuronal activity in response to the prearranged signal which caused limb search­ing motion is revealed. This activity consisted of excitation in response to prearranged flick and inhibition which preceded and accompanied reflex motion. Cessation of impulse discharge generation under acute stress testifies the correlation between the animal emotional state and neuronal activity. D2-receptors antagonist sulpyride is shown to resume stress–injured activity by increasing food motivation and neuronal background activity and by strengthening inhibition concerned with conditioned reflex motion.

Keywords: : impulse activity, prefrontal cortex, conditioned reflex, D-2 receptors, sulpyride, rats

Full text: (PDF, in Ukrainian)

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