Antioxidants prevent experimental hemiparkinsonism in rats
S.A. Talanov, V.F. Sahach.
O.O. Bogomoletz Institute of Physiology, NationalAcademy of Sciences of Ukraine, Kyiv
Abstract
We studied the influence of antioxidants (trolox, melatonin and
coenzyme Q 10) on 6-hydroxydopamine-induced degeneration in
the substantia nigra dopaminergic neurons from the left brain
hemisphere. In rats, the level of unilateral degeneration of
nigrostriatal dopaminergic system was estimated on the base
of an intensity of rotation movements which were contralateral
to denervated hemishere and resulted from systemic injections
of a dopamine receptor agonist apomorphine. It has been shown
that all tested antioxidants reduced a number of animals with
apomorphine-induced behavioral asymmetry in a different de-
gree: coenzyme Q 10) reduced it twofold, trolox – fivefold and
melatonin – sevenfold. We suggest that a neuroprotective ef-
fects of trolox, melatonin and coenzyme Q 10) are associated with
their ability to block the mitochondrial pore openings in the
nervous cells under exploration, and this is the way to prevent
apoptotic death. An oxidative stress has been proved to take
part in the apoptosis in dopamine-producing neurons in the sub-
stantia nigra, and tested antioxidants have been shown to be
effective in preventing neurodegeneration.
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