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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2008; 54(4): 16-22


A hyperpolarization-activated current in rat menthol-sensitive sensory neurons

A. P. Kondratskyi, K. O. Kondratska, G. V. Sotkis, V.G. Naidenov, Ia. M. Shuba.

    International Center of Molecular Physiology, NationalAcademy of Sciences of Ukraine, Kyiv;O.O. Bogomoletz Institute of Physiology, NationalAcademy of Sciences of Ukraine, Kyiv


Abstract

In the present study we have investigated the correlation be- tween hyperpolarization-activated current (Ih) and menthol-ac- tivated current (ITRPM8) in rat dorsal root ganglion (DRG) neurons. We showed that Ih is present in 89% of menthol-sensitive neurons which makes its presence reliable, though not absolute, criterion for pre-selection of such neurons. Endogenous Ih recorded from different neurons exhibited variable density and activation kinetics. Based on the analysis of Ih activation kinetics we hy- pothesize that the population of hyperpolarization-activated channels in menthol-sensitive DRG neurons is mainly represented by HCN1, HCN2 and HCN3 channels. The expression of HCN4 isoform in these cells is very low.

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