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CIRCADIAN CHANGES OF THE DENSITY OF MELATONIN RECEPTORS 1A IN THE NEURONS OF THE SUPRACHIASMATIC NUCLEI OF THE RAT HYPOTHALAMUS UNDER CONDITIONS OF DIVERSE FUNCTIONAL ACTIVITY OF THE PINEAL GLAND
V.P. Pishak, R.Ye. Bulyk
Bukovininan State Medical University, Chernivtsi, Ukraine
DOI: https://doi.org/10.15407/fz54.04.011
Abstract
An immunohistochemical study of the density of melatonin
receptors 1A in the neurons of the rat suprachiasmatic nuclei
with diverse functional activity of the pineal gland has been
carried out. The density of melatonin receptors 1A under condi-
tions of the physiological function of the pineal gland was
characterized by clear-cut diurnal variations. Simultaneously, a
dysfunction of the gland results in their marked disturbance. In
case of a hypofunction of the pineal body the density of the
structures was reliably lower than in case of hyperfunction. It
has been demonstrated that in case of a suppressed activity of
the pineal body the maximum number of melatonin receptors
1A in the neurons of the hypothalamic suprachiasmatic nuclei
shifts from 02.00 a.m. to 02.00 p.m. and constitutes 0,35±0,012
conventional units (c.u.) of density, whereas a larger index is
noticed at 20 hours making up 0,43±0,015 c.u. of density when
the gland is activated.
Keywords:
MELATONIN RECEPTORS 1A, NEURONS, SUPRACHIASMATIC NUCLEI, HYPOTHALAMUS, PINEAL GLAND
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