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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2008; 54(3): 22-27


peculiarities of stress-reactivity of hypothalamo-pituitary-adrenal system inprenatally stressed rats exposed of dexamethasone in prenatal period

N. D. Nosenko.

    V. P. Komissarenko Institute of Endocrinology and Metabolism, Kiev, Ukraine


Abstract

The protective effect of dexamethasone, a synthetic agonist of glucocorticoids, on the functional activity of hypothalamo- pituitary-adrenal system (HPAS) in adult offspring in both genders whose mothers were subject to immobilization stress in last trimester of pregnancy, has been studied. Dexametha- sone treatment prior to stressing pregnant rats prevented the manifestations of injuring effect of prenatal stress on HPAS activity in adult male offspring. The post-stressor changes in hypothalamic noradrenaline content and corticosterone level in blood plasma, as well as GABAA and GABAB receptors activity, did not differ from normal indices. In prenatally stressed female rats no preventive effect of dexamethasone has been reported. The results of investigations suggest the pathogenetic role of increased production of glucocorticoids in Особливості стресової реакції ISSN 0201-8489 Фізіол. журн., 2008, Т. 54, № 3 27 mediating the mechanisms of prenatal stress effects in gender- related functional disorders of HPAS. They demonstrate the possibility of pharmacological prevention of some congenital forms of neuroendocrine pathology and determine the necessity of a gender approach when developing preventive strategies.

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