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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2008; 54(3): 22-27

peculiarities of stress-reactivity of hypothalamo-pituitary-adrenal system inprenatally stressed rats exposed of dexamethasone in prenatal period

N. D. Nosenko.

    V. P. Komissarenko Institute of Endocrinology and Metabolism, Kiev, Ukraine



Abstract

The protective effect of dexamethasone, a synthetic agonist of glucocorticoids, on the functional activity of hypothalamo- pituitary-adrenal system (HPAS) in adult offspring in both genders whose mothers were subject to immobilization stress in last trimester of pregnancy, has been studied. Dexametha- sone treatment prior to stressing pregnant rats prevented the manifestations of injuring effect of prenatal stress on HPAS activity in adult male offspring. The post-stressor changes in hypothalamic noradrenaline content and corticosterone level in blood plasma, as well as GABAA and GABAB receptors activity, did not differ from normal indices. In prenatally stressed female rats no preventive effect of dexamethasone has been reported. The results of investigations suggest the pathogenetic role of increased production of glucocorticoids in Особливості стресової реакції ISSN 0201-8489 Фізіол. журн., 2008, Т. 54, № 3 27 mediating the mechanisms of prenatal stress effects in gender- related functional disorders of HPAS. They demonstrate the possibility of pharmacological prevention of some congenital forms of neuroendocrine pathology and determine the necessity of a gender approach when developing preventive strategies.

Full text: (PDF, in Ukrainian)

References

  1. Балашов Ю.Г. Флюориметрический микрометод определения кортикостерона: сравнение с другими методами // Физиол. журн. СССР. – 1990. – 76, № 2. –С. 280–283.
  2. Носенко Н.Д., Мишунина Т.М. Пренатальная глюкокортикоидная модификация ГАМК-эргической регуляции стресс-реактивности гипоталамогипофизарно-адренокортикальной системы у взрослых крыс // Нейрофизиология. – 2005. – 37, № 3. – С. 244–249.
  3. Пішак В.П., Ткачук С.С., Мислицький В.Ф. Роль ГАМК-ергічної системи мозку в механізмах обмеження стрес-реакції у інтактних та пренатально стресованих самців щурів // Буковин. мед. вісн. –1998. – № 4. – С.157–161.
  4. Резніков О.Г., Носенко Н.Д. Перинатальна стресова модифікація реактивності гіпоталамо-гіпофізарно- надниркової системи // Фізіол. журн. – 2000. – 46,№ 2. – С.146–159
  5. Резников А.Г., Носенко Н.Д., Тарасенко Л.В. и др. Половые особенности нейроэндокринных эффектов пренатального воздействия экзогенных глюкокор- тикоидов // Рос. физиол. журн. им. И. М. Сеченова. –2006. – 92, № 2. – С. 238–248.
  6. Резников А.Г., Пишак В.П., Носенко Н.Д., Ткачук С.С., Мыслицкий В.Ф. Пренатальный стресс и нейроэндокринная патология. – Чернівці: Медака- демія, 2004. – 320 с.
  7. Burton P. J., Waddell B. J. Dual function of 11- hydroxysteroid dehydrogenase in placenta: modulat- ing placental glucocorticoid passage and local steroid action // Biol. Reprod. – 1999. – 60. – P. 234–240.
  8. Challis J.R.G., Matthews S.G., Gibb W., Lye S.J. En- docrine and paracrine regulation of birth at term and preterm // Endocrine Rev. – 2000. – 21. – P.514–550.
  9. 9. Douglas A.J., Johnstone H.A., Wigger A. et al. The role of endogenous opioids in neurohypophysial and hypothalamo-pituitary-adrenal axis hormone secretory responses to stress in pregnant rats // J. Endocrinol. –1998. – 158. – P.285–293.
  10. 10. Edwards C.R.W., Benediktsson R., Lindsay R.S., Seckl J.R. 11?-Hydroxysteroid dehydrogenase: key enzymes in determining tissue-specific glucocorticoid effects // Steroids. – 1996. – 61. – P. 263–269.
  11. Felszeghy K., Bagdy G., Nyakas C. Blunted pituitary- adrenocortical stress response in adult rats following neonatal dexamethasone treatment // J. Neuroendo- crinol. – 2000. – 12. – P.1014–1021.
  12. Jacobowitz D., Richardson J. Method for the rapid determination of norepinephrine, dopamine and sero- tonin in the same brain region // Pharmacоl. Biochem. Behav. – 1978. – 8. – P. 515–519.
  13. Kalabis G.M., Kostaki A., Andrews M.H. et al.Multidrug resisitance phosphoglycoprotein (ABCB1) in the mouse placenta: fetal protection // Biol. Reprod. – 2005. – 73, № 4. – P. 591–597.
  14. Kapoor A., Dunn E., Kostaki A. et al. Fetal program- ming of hypothalamo-pituitary-adrenal function: pre- natal stress and glucocorticoids // J. Physiol. – 2006. – 572. – P. 31–44.
  15. Liu L., Li A., Matthews S.G. Maternal glucocorticoid treatment programs HPA regulation in adult offspring: sex-specific effects // Amer. J. Physiol. Endocrinol. and Metabol.– 2001.– 280. – P. 729-739.
  16. Mairesse J., Lesage J., Breton C. et al. Maternal stress alters endocrine function of the feto-placental unit in rats // Ibid. – 2007. – 292, № 6. – E1526–1533.
  17. Pereira O.C., Arena A.C., Yasuhara F., Kempinas W.G.Effects of prenatal hydrocortisone acetate exposure on fertility and sexual behavior in male rats // Regul. Toxicol. Pharmacol. – 2003. – 38, № 1. – P. 36–42.
  18. Ward I.L., Weisz J. Differential effects of maternal stress on circulating levels of corticosterone, progest- erone and testosterone in male and female rat fetuses and their mothers // Endocrinology. – 1984. – 114,№ 5. – P. 1635–1643.
  19. 19. Welberg L.A., Seckl J.R., Holmes M.C. Prenatal gluco- corticoid programming of brain corticosteroid receptors and corticotropin-releasing hormone: possible impli-cations for behaviour // Neuroscience. – 2001. – 104. –P. 71-79.
  20. 20. Welberg L.A., Thriviktraman K.V., Plotsky P.M. Chronic maternal stress inhibits the capacity to up-regulate placental 11beta-hydroxysteroid dehydrogenase type 2 activity// J. Endocrinol. – 2005. –186. – R7–R12.
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