We studied the influencing of designed during 28 days alimentary deprivation on the bone tissue physiological re- Рис. 4. Зміни концентрації глікозаміногліканів у сироватці крові контрольних (І, ІІІ) та дослідних (ІІ, IV) щурів різного віку: 3 і 9 міс відповідно І.Г. Літовка, О.С. Костюченко 47ISSN 0201-8489 Фізіол. журн., 2008, Т. 54, № 2 modeling processes for 3- and 9-monthly Wistar rats-males (n=32). 4 groups of animals are probed: I, III – control, II, IV is the mode of calorie limitation (40% in relation to a valuable ration for every age group). It is shown, that alimentary dep- rivation increase the concentration of melatonin, glycosami- noglycans in blood serum and activity of alkaline phosphatase in serum and bone tissue in 1,4 and 1,2 time accordingly at for young rats. For adult rats the reliable decline of activity of alkaline phosphatase is exposed in the blood serum after alimentary deprivation. Expression of gene of insulinlike growth factor-I for animals of both probed groups did not change practically. We conclude, that alimentary deprivation change the biochemical markers of bone tissue physiological remodel- ing for young animals, while the changes of physiological regeneration rates were insignificant for adult animals.