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Calcium signaling in carcinogenesis
Ia. M. Shuba.
International Center of Molecular Physiology, NationalAcademy of Sciences of Ukraine
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Abstract
Malignant transformation of the cells in cancer is caused by
excessive proliferation accompanied by diminished ability for
apoptosis due to the loss of normal control on these pro-
cesses. Despite their ubiquity calcium ions are central to both
processes, serving as major signalling agents. The present review
examines what changes in calcium distribution among various
compartments: extracellular space, cytoplasm, endoplasmic
reticulum and mitochondria take place during transition from
normal to pathological cell growth and death, what Ca2+-han-
dling proteins are involved, and how this affects spatial and
temporal characteristics of Ca2+ signals aimed at regulating
specific cellular responses. Uncovering the underlying mo-
lecular events may help elaborating new strategies for cancers
treatment.
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