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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2007; 53(4): 110-128


Calcium signaling in carcinogenesis

Ia. M. Shuba.

    International Center of Molecular Physiology, NationalAcademy of Sciences of Ukraine


Abstract

Malignant transformation of the cells in cancer is caused by excessive proliferation accompanied by diminished ability for apoptosis due to the loss of normal control on these pro- cesses. Despite their ubiquity calcium ions are central to both processes, serving as major signalling agents. The present review examines what changes in calcium distribution among various compartments: extracellular space, cytoplasm, endoplasmic reticulum and mitochondria take place during transition from normal to pathological cell growth and death, what Ca2+-han- dling proteins are involved, and how this affects spatial and temporal characteristics of Ca2+ signals aimed at regulating specific cellular responses. Uncovering the underlying mo- lecular events may help elaborating new strategies for cancers treatment.

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