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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2007; 53(4): 35-42

Inhibition of mitochondrial permeability transition pore is one of the mechanisms ofcardioprotective effect of coenzyme Q10

V.F.Sagach, G.L.Vavilova, O.V.Rudyk, F.V.Dobrovolsky, T.V.Shimanskaya, O.S.Medvedev

    O.O.Bogomoletz Institute of Physiology, NAS of Ukraine, Kyiv.



Abstract

Protective properties of coenzyme Q10 (CоQ10) on the: (i) Langendorff isolated guinea pig heart’s function under ischemia and reperfusion (I/R) and on the isolated mitochondria (ii) the mitochondrial permeability transition pore (MPTP) opening under exposure to calcium as natural MPTP inductor and phenylarsine oxide as oxidant - were studied. Physiological characteristic of contractile function, myocardial oxygen consumption and mitochondrial factor release as index of MPTP opening were compared before and after ischemia of isolated heart in control animals and animals with preliminary administration of CоQ10 per os . It have been shown that I/R disturbances of heart function were decreased and oxygen metabolism was normalised in animals treated with CоQ10 in compare to non-treated control. It was accompanied with sub- stantial stabilization of mitochondrial membrane. Decreased I/R disturbances of isolated heart from CоQ10 -treated animals were correlated to amount of mitochondrial factor released to coronary flow. Moreover, preliminary incubation of mitochon- dria, isolated from rat heart, with CоQ10 (10-5 mol/l) substan- tially prevented calcium and phenylarsine–induced, cyclosporine A-sensitive mitochondrial swelling. This protec- tive effect was increased in experiments with deenergizing mitochondria. Results of physiological and biochemical study reveal that one of the mechanisms of CоQ10‘s cardioprotective effect could be direct inhibition of mitochondrial permeability tran- sition pore opening during ischemia and reperfusion of the heart.

Full text: (PDF, in Ukrainian)

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