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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2007; 53(3): 70-77


Functional-metabolic basis of nitricoxide derivates modulatory influ-ence in brain underthe condition of hemic hypoxia

M.R.Gzhegotsky, L.V.Panina, O.I.Terletska,S.M.Kovalchuk.

    Lviv National Medical University named after DanyloHalytsky, Ukraine



Free radical homeostasis parameters of rat’s brain mitochon- dria under conditions of sodium nitrite administration at the peak of hypoxia had been studied. Prior to study experimental animals have been divided into two groups depending on resistance to hypobaric hypoxia. In brain mitochondria of high-resistant to hypoxia rats increase of the nitrites-ions contents and also in- tensification of pro- and antioxidative processes were registered in comparison with the control group. Decrease of all investgated free radical homeostasis parameters in brain mitochondria of low-resistant to hypoxia animals in comparison with the control group was determined. Administration of pro-hypoxic factor in toxic dose allowed us to reveal specific peculiarities of redox processes development in the brain mitochondria of experimen- tal animals with different resistance to hypoxia.

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2025.