Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2007; 53(2): 90-97


Mitochondriain oocytes and embryos

T.V. Blashkiv, T.Yu. Voznesenskaya, R.I. Yanchiy

    O.O.Bogomoletz Institute of Physiology, NationalAcademy of Science of Ukraine



Abstract

The review considers such factors as mitochondrial distribution, fine structure, mitochondrial carriers and metabolic activity, as well as polarity of mitochondria and their participation in free intracellular Ca2+ regulation in mammalian oocytes and embryos.

References

  1. Вознесенская Т., Блашкив Т., Портниченко А.Влияние кумулюсных и гранулярных клеток навозобновление мейоза ооцитами мышей in vitro //Цитология. – 2001. – 43, №3. – С. 250 - 253.
  2. Вознесенская Т.Ю. Влияние ингибиторов митохонд-риальных переносчиков на мейотическое созреваниеооцитов мышей / Тезы докл. 4-й Всерос. конф. смеждунар. участием (4–6 окт. 2005 г., Санкт-Петербург). – СПб, 2005. – С. 58.
  3. Ahn H., Sohn I., Kwon H. et al. Characteristics of the cellmembrane fluidity, actin fibers, and mitochondrial dys-functions of frozenthawed two-cell mouse embryos //Mol. Reprod. and Develop. – 2002. – 61. – P. 466–476.
  4. Aw T. Intracellular compartmentalization of organellesand gradients of low molecular weight species // Int.Review Cytol. – 2000. – 192. – P. 223–253.
  5. Babcock D., Herrington J., Goodwin P. et al. Mito-chondrial participation in the intracellular Ca2+network// J. Cell Biol. – 1997. – 136. – P. 833–844.
  6. Barnett D., Kimura J., Bavister B. Translocation of ac-tive mitochondria during hamster preimplantation embryodevelopment studied by confocal laser scanning micros-copy // Develop. Dynamics. – 1996. – 205. – P. 64–72.
  7. Barrit J., Kokot M., Cohen J., Brenner C. Quantifica-tion of human ooplasmic mitochondria // Reprod.Bioмed. Online. – 2002. – 4. – P. 243–247.
  8. Bavister B., Squirrell J. Mitochondrial distribution andfunction in oocytes and early embryos // Hum. Reprod.– 2000. – 15, №2. – P. 189–198.
  9. 9. Berridge M., Bootman M., Lipp P. Calcium – a life anddeath signal // Nature. – 1998. – 395. – P. 645–648.
  10. 10. Cavero S., Vozza A., del Arco A. et al. Identificationand metabolic role of the mitochondrial aspartate-glutamate transporter in Saccharomyces cerevisiae //Mol. Microbiol. – 2003. – 50, №4. – P. 1257–1269.
  11. Chinnery P. New approaches to the treatment of mito-chondrial disorders // Reprod. Bioмed. Online. – 2004. –8. – P. 16–23.
  12. Christodoulou J. Genetic defects causing human mito-chondrial respiratory chain disorders and disease //Hum. Reprod. – 2000. – 15, №2. – P. 28–43.
  13. Clayton D. Transcription and replication of mitochon-drial DNA // Ibid. – 2000. – 15, №2. – P. 11–17.
  14. Crimi M., O’Hearn S., Wallace D., Comi G. Molecularresearch technologies in mitochondrial diseases: themicroarray approach // IUBMB Life. – 2005. – 57,№12. – P. 811–818.
  15. Cummins J. The role of maternal mitochondria duringoogenesis, fertilization and embryogenesis // Reprod.Biomed. Online. – 2002. – 4. – P. 176–182.
  16. del Arco A., Satrustegui J. Characterization of a sec-ond member of the subfamily of calcium-binding mito-chondrial carriers expressed in human non-excitabletissues // Biochem. J. – 2000. – 345, №3. – P. 725–732.
  17. Diaz G., Setzu M., Zucca A. et al. Subcellular hetero-geneity of mitochondrial membrane potential:relationship with organelle distribution and intercellu-lar contacts in normal, hypoxic and apoptotic cells // J.Cell Science. – 1999. – 112. – P. 1077–1084.
  18. Duchen M. Mitochondria and calcium: from cell signal-ling to cell death // J. Physiol. – 2000. – 529. – P. 57–68.
  19. 19. Dumollard R., Hammar K., Porterfield M. et al. Mito-chondrial respiration and Ca2+-waves are linked duringfertilisation and meiosis completion // Development. –2003. – 130. – P. 683–692.
  20. 20. Dumollard R., Marangos P., Fitzharris G. et al. Sperm-triggered [Ca2+] oscillations and Ca2+ homeostasis in themouse egg have an absolute requirement for mitochondrialATP production // Ibid. – 2004. – 131. – P. 3057–3067.
  21. Dvorak M., Travnik P., Hanzelka Z. et al. Ultrastruc-tural and morphometric analysis of cytoplasmic struc-tures in human oocytes obtained from tertiary ovarianfollicles // Scripta Medica. – 1987. – 60. – P. 131–140.
  22. Eto K., Suga S., Wakui M., et al. NADH shuttle sys-tem regulates K(ATP) channel-dependent pathway andsteps distal to cytosolic Ca(2+) concentration eleva-tion in glucose-induced insulin secretion // J. Biol. Chem. –1999. – 274, №36. – P. 25386–25392.
  23. Eto K., Tsubamoto Y., Terauchi Y. et al. Role of NADHshuttle system in glucose-induced activation of mito-chondrial metabolism and insulin secretion // Science. –1999. – 283, № 5404. – P. 981–985.
  24. Fiermonte G., De Leonardis F., Todisco S. et al. Iden-tification of the mitochondrial ATP-Mg/Pi transporter.Bacterial expression, reconstitution, functional charac-terization, and tissue distribution // J. Biol. Chem. –2004. – 279, №29. – P. 30722–30730.
  25. Fiermonte G., Palmieri L., Todisco S. et al. Identifica-tion of the mitochondrial glutamate transporter. Bac-terial expression, reconstitution, functional characte-rization, and tissue distribution of two human isoforms// Ibid. – 2002. – 277, №22. – P. 19289–19294.
  26. Gaulden M. Maternal age effect: the enigma of Downsyndrome and other trisomic conditions // MutationRes. – 1992. – 296. – P. 69–88.
  27. Hajnoczky G., Gyorgy C., Muniswamy M., Pacher P.The machinery of local calcium signalling betweensarco-endoplasmic reticulum and mitochondria // J.Physiol. – 2000. – 529. – P. 69–81.
  28. Hoek J., Coll K., Williamson J. Kinetics of glutamateefflux in rat liver mitochondria // J. Biol. Chem. – 1983. –258, № 1. – P. 54–58.
  29. 29. Hussein M. Apoptosis in the ovary: molecular mecha-nisms // Hum. Reprod. Update. – 2005. – 11, № 2. –P. 162–177.
  30. 30. Ichas F., Jouaville L., Mazat J. Mitochondria are excit-able organelles capable of generating and conveyingelectrical and calcium signals // Cell. – 1997. – 89. –P. 1145–1153.
  31. Indiveri C., Abruzzo G., Stipani I., Palmieri F. Identi-fication and purification of the reconstitutively activeglutamine carrier from rat kidney mitochondria //Biochem. J. – 1998. – 333, № 2. – P. 285–290.
  32. Jansen R. Germline passage of mitochondria: quantita-tive considerations and possible embryological sequelae// Hum. Reprod. – 2000. – 15, № 2. – P. 112–128.
  33. Jones A., Van Blerkom J., Davis P., Toledo A. Cryo-preservation of metaphase II human ooocytes affectsmitochondrial inner membrane potential: implicationsfor developmental competence // Ibid. – 2004. – 19. –P. 1861–1866.
  34. LaNoue K., Schoolwerth A. Metabolite transport inmitochondria // Annu. Rev. Biochem. – 1979. – 48. –P. 871–922.
  35. Leonard J., Schapira A. Mitochondrial respiratory chaindisorders. Mitochondrial DNA defects // Lancet. – 2000. –
  36. – P. 299–304.36. Liu H., Keefe D. Cytoplasm mediates both developmen-tal and oxidation-induced apoptotic cell death in mousezygotes // Biol. Reprod. – 2000. – 62. – P. 1828–1834.
  37. Liu L., Hammar K., Smith P. et al. Mitochondrial modu-lation of calcium signaling at the initiation of develop-ment // Cell Calcium. – 2001. – 30. – P. 423–433.
  38. Menezo Y. Paternal and maternal factors in preimplan-tation embryogenesis: interaction with the biochemi cal environment // Reprod. Biomed. Online. – 2006. –12, №5. – P. 616–621.39. Mengual R., El Abida K., Mouaffak N. et al. Pyruvateshuttle in muscle cells: high-affinity pyruvate trans-port sites insensitive to trans-lactate efflux // Amer. J.Physiol. Endocrinol. Metab. – 2003. – 285, № 6. –P. 1196–1204.
  39. 40. Motta P., Nottola S., Familiari G. et al. Morpho-dynamics of the follicular–luteal complex during earlyovarian development and reproductive life // Intern.Rev. Cytol. – 2003. – 223. – P. 177– 88.
  40. Motta P., Nottola S., Makabe S., Heyn R Mitochon-drial morphology in human fetal and adult female germcells // Hum. Reprod. – 2000. – 15, №2. – P. 129–147.
  41. Muller-Hocker J., Schafer S., Weis S. et al. Morpho-logical, cytochemical and molecular genetic analysesof mitochondria in isolated human oocytes in thereproductive age // Mol. Hum. Reprod. – 1996. – 2. –P. 951–958.
  42. Ozil J., Huneau D. Activation of rabbit oocytes: theimpact of the Ca2+ signal regime on development //Development. – 2001. – 128. – P. 917–928.
  43. Palmieri F., Stipani I., Iacobazzi V. The transport of L-cysteinesulfinate in rat liver mitochondria // Biochim.Biophys Acta. – 1979. – 555, №3. – P. 531–546.
  44. Pozzan T., Magalhaes P., Rizzuto R. The comeback ofmitochondria to calcium signalling // Cell Calcium. –2000. – 28. – P. 279–283.
  45. Reers M., Smith T., Chen L. J-aggregate formation of acarbocyanine as a quantitative fluorescent indicator ofmembrane potential // Biochemistry. – 199. – 130. –P. 4480–4486.
  46. Reynier P., May-Panloup P., Chretien M. et al. Mito-chondrial DNA content effects the fertilizability ofhuman oocytes // Mol. Hum. Reproduction. – 2001. –7. – P. 425–429.
  47. Rizzuto R., Bastianutto M., Brini M. et al. Mitochon-drial Ca2+homeostasis in intact cells // J. Cell Biol. –1994. – 126. – P. 1183–1194.
  48. 49. Roesch K., Hynds P., Varga R. et al. The calcium-bind-ing aspartate/glutamate carriers, citrin and aralar1, arenew substrates for the DDP1/TIMM8a-TIMM13complex // Hum. Mol. Genet. – 2004. – 13, № 18. –P. 2101–2111.
  49. 50. Rubi B., del Arco A., Bartley C. et al. The malate-aspar-tate NADH shuttle member Aralar1 determines glucosemetabolic fate, mitochondrial activity, and insulin secretionin beta cells // J. Biol. Chem. – 2004. – 279, №53. –P. 55659–55666.
  50. Rupert B., Segar J., Schutte B., Scholz T. Metabolic adap-tation of the hypertrophied heart: role of the malate/aspar-tate and alpha-glycerophosphate shuttles // J. Mol. CellCardiol. – 2000. – 32, № 12. – P. 2287–2297.
  51. Rutter G., Rizzuto R. Regulation of mitochondrialmetabolism by ER Ca2+release: an intimate connection// TIBS. – 2000. – 25. – P. 215–220.
  52. Scholz T., Koppenhafer S. ten Eyck C., Schutte B.Ontogeny of malate-aspartate shuttle capacity andgene expression in cardiac mitochondria // Amer. J.Physiol. – 1998. – 274, № 3. – P. C780–C788.
  53. Schoolwerth A., LaNoue K. The role of microcom-partmentation in the regulation of glutamate metabo-lism by rat kidney mitochondria // J. Biol. Chem. –1980. – 55, №8. – P. 3403–3411.
  54. Schoolwerth A., Nazar B., LaNoue K. Glutamate de-hydrogenase activation and ammonia formation by ratkidney mitochondria // Ibid. – 1978. – 253, № 17. –P. 6177–6183.
  55. Schwartz M., Vissing J. New patterns of inheritancein mitochondrial disease // Biochem. and Biophys. Res.Communs. – 2003. – 310. – P. 247–251.
  56. Smiley S., Reers M., Mottloa-Hartshorn C. et al. In-tracellular heterogeneity in mitochondrial membranepotentials revealed by H-aggregate-forming lipophiliccation JC-1 // PNAS. – 1991. – 88. – P. 3671–3675.
  57. Sotelo J., Porter K. An electron microscopic study ofthe rat ovum // J. Biophys. and Biochem. Cytol. –1959. – 5. – P. 327–342.
  58. 59. Sousa M., Barros A., Tesarik J. Developmental changes incalcium dynamics, protein kinase C distribution and endoplas-mic reticulum organization in human preimplantation stageembryos // Mol. Hum. Reprod. – 1996. – 2. – P. 967–977.
  59. 60. Steuerwald N., Barrit J., Adler R. et al. Quantificationof mtDNA in single oocytes, polar bodies and subcel-lular components by real-time rapid cycle fluorescencemonitored PCR // Zygote. – 2000. – 9. – P. 209–215.
  60. Sugiura K., Pendola F., Eppig J. Oocyte control ofmetabolic cooperativity between oocytes and compa-nion granulosa cells: energy metabolism // Dev. Biol. –2005. – 279, № 1. – P. 20–30.
  61. Sun Q., Schatten H. Regulation of dynamic events bymicrofilaments during oocyte maturation and fertiliza-tion // Reproduction. – 2006. – 131, № 2. – P. 193–205.
  62. Sutovsky P. Degradation of paternal mitochondria af-ter fertilization: implications for heteroplasmy, as-sisted reproductive technologies and mtDNA inheri-tance // Reprod. Biomed. Online. – 2004. – 8. – P. 24–33.
  63. Tarazona A., Rodriguez J., Restrepo L., Olivera-AngelM. Mitochondrial activity, distribution and segregationin bovine oocytes and in embryos produced in vitro //Reprod. Domest. Anim. – 2006. – 41, № 1. – P. 5–11.
  64. Tesarik J. Calcium signalling in human oocytes andembryos: two-store model revival // Hum. Reprod. –2002. – 17. – P. 2948–2949.
  65. Tokura T., Noda Y., Goto Y., Mori T. Sequential obser-vations of mitochondrial distributions in mouse oo-cytes and embryos // J. Assis. Reprod. and Genetics. –1993. – 10. – P. 417–426.
  66. Van Blerkom J., Runner M. Mitochondrial reorganiza-tion during resumption of arrested meiosis in the mouseoocyte // Amer. J. Anat. – 1984. – 171. – P. 335–355.
  67. Van Blerkom J. Microtubule mediation of cytoplasmicand nuclear maturation during the early stages ofresumed meiosis in cultured mouse oocytes // PNAS. –1991. – 88. – P. 5031–5035.
  68. 69. Van Blerkom J. Development of human embryos to thehatched blastocyst stage in the presence or absence ofa monolayer of Vero cells // Hum. Reprod. – 1993. – 8.– P. 1525–1539.
  69. 70. Van Blerkom J., Davis P., Alexander S. Differentialmitochondrial inheritance between blastomeres incleavage stage human embryos: determination at thepronuclear stage and relationship to microtubularorganization, ATP content and developmentalcompetence // Ibid. – 2000. – 15. – P. 2621–2633.
  70. Van Blerkom J., Davis P., Lee J. ATP content of humanoocytes and developmental potential and outcome afterin vitro fertilization and embryo transfer // Ibid. – 1995.– 10. – P. 415–424.
  71. Van Blerkom J., Davis P., Mathwig V., Alexander S.Domains of high-polarized and low-polarized mito-chondria may occur in mouse and human oocytes andearly embryos // Ibid. – 2002. – 17. – P. 393–406.
  72. Wilding M., Dale B., Marino M. et al. Mitochondrialaggregation patterns and activity in human oocytes andpreimplantation embryos // Ibid. – 2001. – 16. –P. 909–917.
  73. Wilding M., De Placido G., De Matteo L. et al. Chaoticmosaicism in human preimplantation embryos iscorrelated with a low mitochondrial membrane poten-tial // Fertil. and Steril. – 2003. – 79. – P. 340–346.
  74. Wilding M., Fiorentino A., De Simone M. et al. Energysubstrates, mitochondrial membrane potential andhuman preimplantation embryo division // Reprod.Biomed. Online. – 2002. – 5. – P. 39–42.
  75. Zjubina A., Blashkiv T., Voznesenskaya T., YanchiyR. The influence of the mitochondrial carriers inhibi-tors on murine oocyte meiotic maturation in thecumulus-oocyte-cellular complexes // Зб. тез ІІ міжнар.наук. конф. студентів та аспірантів (21–24 бер. 2006р., Львів). – Львів, 2006. – C. 451–452.

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.