Mitochondriain oocytes and embryos
T.V. Blashkiv, T.Yu. Voznesenskaya, R.I. Yanchiy
O.O.Bogomoletz Institute of Physiology, NationalAcademy of Science of Ukraine
![](/images/cite.png)
Abstract
The review considers such factors as mitochondrial distribution,
fine structure, mitochondrial carriers and metabolic activity,
as well as polarity of mitochondria and their participation in
free intracellular Ca 2+ regulation in mammalian oocytes and
embryos.
References
- Вознесенская Т., Блашкив Т., Портниченко А.Влияние кумулюсных и гранулярных клеток навозобновление мейоза ооцитами мышей in vitro //Цитология. – 2001. – 43, №3. – С. 250 - 253.
- Вознесенская Т.Ю. Влияние ингибиторов митохонд-риальных переносчиков на мейотическое созреваниеооцитов мышей / Тезы докл. 4-й Всерос. конф. смеждунар. участием (4–6 окт. 2005 г., Санкт-Петербург). – СПб, 2005. – С. 58.
- Ahn H., Sohn I., Kwon H. et al. Characteristics of the cellmembrane fluidity, actin fibers, and mitochondrial dys-functions of frozenthawed two-cell mouse embryos //Mol. Reprod. and Develop. – 2002. – 61. – P. 466–476.
- Aw T. Intracellular compartmentalization of organellesand gradients of low molecular weight species // Int.Review Cytol. – 2000. – 192. – P. 223–253.
- Babcock D., Herrington J., Goodwin P. et al. Mito-chondrial participation in the intracellular Ca2+network// J. Cell Biol. – 1997. – 136. – P. 833–844.
- Barnett D., Kimura J., Bavister B. Translocation of ac-tive mitochondria during hamster preimplantation embryodevelopment studied by confocal laser scanning micros-copy // Develop. Dynamics. – 1996. – 205. – P. 64–72.
- Barrit J., Kokot M., Cohen J., Brenner C. Quantifica-tion of human ooplasmic mitochondria // Reprod.Bioмed. Online. – 2002. – 4. – P. 243–247.
- Bavister B., Squirrell J. Mitochondrial distribution andfunction in oocytes and early embryos // Hum. Reprod.– 2000. – 15, №2. – P. 189–198.
- 9. Berridge M., Bootman M., Lipp P. Calcium – a life anddeath signal // Nature. – 1998. – 395. – P. 645–648.
- 10. Cavero S., Vozza A., del Arco A. et al. Identificationand metabolic role of the mitochondrial aspartate-glutamate transporter in Saccharomyces cerevisiae //Mol. Microbiol. – 2003. – 50, №4. – P. 1257–1269.
- Chinnery P. New approaches to the treatment of mito-chondrial disorders // Reprod. Bioмed. Online. – 2004. –8. – P. 16–23.
- Christodoulou J. Genetic defects causing human mito-chondrial respiratory chain disorders and disease //Hum. Reprod. – 2000. – 15, №2. – P. 28–43.
- Clayton D. Transcription and replication of mitochon-drial DNA // Ibid. – 2000. – 15, №2. – P. 11–17.
- Crimi M., O’Hearn S., Wallace D., Comi G. Molecularresearch technologies in mitochondrial diseases: themicroarray approach // IUBMB Life. – 2005. – 57,№12. – P. 811–818.
- Cummins J. The role of maternal mitochondria duringoogenesis, fertilization and embryogenesis // Reprod.Biomed. Online. – 2002. – 4. – P. 176–182.
- del Arco A., Satrustegui J. Characterization of a sec-ond member of the subfamily of calcium-binding mito-chondrial carriers expressed in human non-excitabletissues // Biochem. J. – 2000. – 345, №3. – P. 725–732.
- Diaz G., Setzu M., Zucca A. et al. Subcellular hetero-geneity of mitochondrial membrane potential:relationship with organelle distribution and intercellu-lar contacts in normal, hypoxic and apoptotic cells // J.Cell Science. – 1999. – 112. – P. 1077–1084.
- Duchen M. Mitochondria and calcium: from cell signal-ling to cell death // J. Physiol. – 2000. – 529. – P. 57–68.
- 19. Dumollard R., Hammar K., Porterfield M. et al. Mito-chondrial respiration and Ca2+-waves are linked duringfertilisation and meiosis completion // Development. –2003. – 130. – P. 683–692.
- 20. Dumollard R., Marangos P., Fitzharris G. et al. Sperm-triggered [Ca2+] oscillations and Ca2+ homeostasis in themouse egg have an absolute requirement for mitochondrialATP production // Ibid. – 2004. – 131. – P. 3057–3067.
- Dvorak M., Travnik P., Hanzelka Z. et al. Ultrastruc-tural and morphometric analysis of cytoplasmic struc-tures in human oocytes obtained from tertiary ovarianfollicles // Scripta Medica. – 1987. – 60. – P. 131–140.
- Eto K., Suga S., Wakui M., et al. NADH shuttle sys-tem regulates K(ATP) channel-dependent pathway andsteps distal to cytosolic Ca(2+) concentration eleva-tion in glucose-induced insulin secretion // J. Biol. Chem. –1999. – 274, №36. – P. 25386–25392.
- Eto K., Tsubamoto Y., Terauchi Y. et al. Role of NADHshuttle system in glucose-induced activation of mito-chondrial metabolism and insulin secretion // Science. –1999. – 283, № 5404. – P. 981–985.
- Fiermonte G., De Leonardis F., Todisco S. et al. Iden-tification of the mitochondrial ATP-Mg/Pi transporter.Bacterial expression, reconstitution, functional charac-terization, and tissue distribution // J. Biol. Chem. –2004. – 279, №29. – P. 30722–30730.
- Fiermonte G., Palmieri L., Todisco S. et al. Identifica-tion of the mitochondrial glutamate transporter. Bac-terial expression, reconstitution, functional characte-rization, and tissue distribution of two human isoforms// Ibid. – 2002. – 277, №22. – P. 19289–19294.
- Gaulden M. Maternal age effect: the enigma of Downsyndrome and other trisomic conditions // MutationRes. – 1992. – 296. – P. 69–88.
- Hajnoczky G., Gyorgy C., Muniswamy M., Pacher P.The machinery of local calcium signalling betweensarco-endoplasmic reticulum and mitochondria // J.Physiol. – 2000. – 529. – P. 69–81.
- Hoek J., Coll K., Williamson J. Kinetics of glutamateefflux in rat liver mitochondria // J. Biol. Chem. – 1983. –258, № 1. – P. 54–58.
- 29. Hussein M. Apoptosis in the ovary: molecular mecha-nisms // Hum. Reprod. Update. – 2005. – 11, № 2. –P. 162–177.
- 30. Ichas F., Jouaville L., Mazat J. Mitochondria are excit-able organelles capable of generating and conveyingelectrical and calcium signals // Cell. – 1997. – 89. –P. 1145–1153.
- Indiveri C., Abruzzo G., Stipani I., Palmieri F. Identi-fication and purification of the reconstitutively activeglutamine carrier from rat kidney mitochondria //Biochem. J. – 1998. – 333, № 2. – P. 285–290.
- Jansen R. Germline passage of mitochondria: quantita-tive considerations and possible embryological sequelae// Hum. Reprod. – 2000. – 15, № 2. – P. 112–128.
- Jones A., Van Blerkom J., Davis P., Toledo A. Cryo-preservation of metaphase II human ooocytes affectsmitochondrial inner membrane potential: implicationsfor developmental competence // Ibid. – 2004. – 19. –P. 1861–1866.
- LaNoue K., Schoolwerth A. Metabolite transport inmitochondria // Annu. Rev. Biochem. – 1979. – 48. –P. 871–922.
- Leonard J., Schapira A. Mitochondrial respiratory chaindisorders. Mitochondrial DNA defects // Lancet. – 2000. –
- – P. 299–304.36. Liu H., Keefe D. Cytoplasm mediates both developmen-tal and oxidation-induced apoptotic cell death in mousezygotes // Biol. Reprod. – 2000. – 62. – P. 1828–1834.
- Liu L., Hammar K., Smith P. et al. Mitochondrial modu-lation of calcium signaling at the initiation of develop-ment // Cell Calcium. – 2001. – 30. – P. 423–433.
- Menezo Y. Paternal and maternal factors in preimplan-tation embryogenesis: interaction with the biochemi cal environment // Reprod. Biomed. Online. – 2006. –12, №5. – P. 616–621.39. Mengual R., El Abida K., Mouaffak N. et al. Pyruvateshuttle in muscle cells: high-affinity pyruvate trans-port sites insensitive to trans-lactate efflux // Amer. J.Physiol. Endocrinol. Metab. – 2003. – 285, № 6. –P. 1196–1204.
- 40. Motta P., Nottola S., Familiari G. et al. Morpho-dynamics of the follicular–luteal complex during earlyovarian development and reproductive life // Intern.Rev. Cytol. – 2003. – 223. – P. 177– 88.
- Motta P., Nottola S., Makabe S., Heyn R Mitochon-drial morphology in human fetal and adult female germcells // Hum. Reprod. – 2000. – 15, №2. – P. 129–147.
- Muller-Hocker J., Schafer S., Weis S. et al. Morpho-logical, cytochemical and molecular genetic analysesof mitochondria in isolated human oocytes in thereproductive age // Mol. Hum. Reprod. – 1996. – 2. –P. 951–958.
- Ozil J., Huneau D. Activation of rabbit oocytes: theimpact of the Ca2+ signal regime on development //Development. – 2001. – 128. – P. 917–928.
- Palmieri F., Stipani I., Iacobazzi V. The transport of L-cysteinesulfinate in rat liver mitochondria // Biochim.Biophys Acta. – 1979. – 555, №3. – P. 531–546.
- Pozzan T., Magalhaes P., Rizzuto R. The comeback ofmitochondria to calcium signalling // Cell Calcium. –2000. – 28. – P. 279–283.
- Reers M., Smith T., Chen L. J-aggregate formation of acarbocyanine as a quantitative fluorescent indicator ofmembrane potential // Biochemistry. – 199. – 130. –P. 4480–4486.
- Reynier P., May-Panloup P., Chretien M. et al. Mito-chondrial DNA content effects the fertilizability ofhuman oocytes // Mol. Hum. Reproduction. – 2001. –7. – P. 425–429.
- Rizzuto R., Bastianutto M., Brini M. et al. Mitochon-drial Ca2+homeostasis in intact cells // J. Cell Biol. –1994. – 126. – P. 1183–1194.
- 49. Roesch K., Hynds P., Varga R. et al. The calcium-bind-ing aspartate/glutamate carriers, citrin and aralar1, arenew substrates for the DDP1/TIMM8a-TIMM13complex // Hum. Mol. Genet. – 2004. – 13, № 18. –P. 2101–2111.
- 50. Rubi B., del Arco A., Bartley C. et al. The malate-aspar-tate NADH shuttle member Aralar1 determines glucosemetabolic fate, mitochondrial activity, and insulin secretionin beta cells // J. Biol. Chem. – 2004. – 279, №53. –P. 55659–55666.
- Rupert B., Segar J., Schutte B., Scholz T. Metabolic adap-tation of the hypertrophied heart: role of the malate/aspar-tate and alpha-glycerophosphate shuttles // J. Mol. CellCardiol. – 2000. – 32, № 12. – P. 2287–2297.
- Rutter G., Rizzuto R. Regulation of mitochondrialmetabolism by ER Ca2+release: an intimate connection// TIBS. – 2000. – 25. – P. 215–220.
- Scholz T., Koppenhafer S. ten Eyck C., Schutte B.Ontogeny of malate-aspartate shuttle capacity andgene expression in cardiac mitochondria // Amer. J.Physiol. – 1998. – 274, № 3. – P. C780–C788.
- Schoolwerth A., LaNoue K. The role of microcom-partmentation in the regulation of glutamate metabo-lism by rat kidney mitochondria // J. Biol. Chem. –1980. – 55, №8. – P. 3403–3411.
- Schoolwerth A., Nazar B., LaNoue K. Glutamate de-hydrogenase activation and ammonia formation by ratkidney mitochondria // Ibid. – 1978. – 253, № 17. –P. 6177–6183.
- Schwartz M., Vissing J. New patterns of inheritancein mitochondrial disease // Biochem. and Biophys. Res.Communs. – 2003. – 310. – P. 247–251.
- Smiley S., Reers M., Mottloa-Hartshorn C. et al. In-tracellular heterogeneity in mitochondrial membranepotentials revealed by H-aggregate-forming lipophiliccation JC-1 // PNAS. – 1991. – 88. – P. 3671–3675.
- Sotelo J., Porter K. An electron microscopic study ofthe rat ovum // J. Biophys. and Biochem. Cytol. –1959. – 5. – P. 327–342.
- 59. Sousa M., Barros A., Tesarik J. Developmental changes incalcium dynamics, protein kinase C distribution and endoplas-mic reticulum organization in human preimplantation stageembryos // Mol. Hum. Reprod. – 1996. – 2. – P. 967–977.
- 60. Steuerwald N., Barrit J., Adler R. et al. Quantificationof mtDNA in single oocytes, polar bodies and subcel-lular components by real-time rapid cycle fluorescencemonitored PCR // Zygote. – 2000. – 9. – P. 209–215.
- Sugiura K., Pendola F., Eppig J. Oocyte control ofmetabolic cooperativity between oocytes and compa-nion granulosa cells: energy metabolism // Dev. Biol. –2005. – 279, № 1. – P. 20–30.
- Sun Q., Schatten H. Regulation of dynamic events bymicrofilaments during oocyte maturation and fertiliza-tion // Reproduction. – 2006. – 131, № 2. – P. 193–205.
- Sutovsky P. Degradation of paternal mitochondria af-ter fertilization: implications for heteroplasmy, as-sisted reproductive technologies and mtDNA inheri-tance // Reprod. Biomed. Online. – 2004. – 8. – P. 24–33.
- Tarazona A., Rodriguez J., Restrepo L., Olivera-AngelM. Mitochondrial activity, distribution and segregationin bovine oocytes and in embryos produced in vitro //Reprod. Domest. Anim. – 2006. – 41, № 1. – P. 5–11.
- Tesarik J. Calcium signalling in human oocytes andembryos: two-store model revival // Hum. Reprod. –2002. – 17. – P. 2948–2949.
- Tokura T., Noda Y., Goto Y., Mori T. Sequential obser-vations of mitochondrial distributions in mouse oo-cytes and embryos // J. Assis. Reprod. and Genetics. –1993. – 10. – P. 417–426.
- Van Blerkom J., Runner M. Mitochondrial reorganiza-tion during resumption of arrested meiosis in the mouseoocyte // Amer. J. Anat. – 1984. – 171. – P. 335–355.
- Van Blerkom J. Microtubule mediation of cytoplasmicand nuclear maturation during the early stages ofresumed meiosis in cultured mouse oocytes // PNAS. –1991. – 88. – P. 5031–5035.
- 69. Van Blerkom J. Development of human embryos to thehatched blastocyst stage in the presence or absence ofa monolayer of Vero cells // Hum. Reprod. – 1993. – 8.– P. 1525–1539.
- 70. Van Blerkom J., Davis P., Alexander S. Differentialmitochondrial inheritance between blastomeres incleavage stage human embryos: determination at thepronuclear stage and relationship to microtubularorganization, ATP content and developmentalcompetence // Ibid. – 2000. – 15. – P. 2621–2633.
- Van Blerkom J., Davis P., Lee J. ATP content of humanoocytes and developmental potential and outcome afterin vitro fertilization and embryo transfer // Ibid. – 1995.– 10. – P. 415–424.
- Van Blerkom J., Davis P., Mathwig V., Alexander S.Domains of high-polarized and low-polarized mito-chondria may occur in mouse and human oocytes andearly embryos // Ibid. – 2002. – 17. – P. 393–406.
- Wilding M., Dale B., Marino M. et al. Mitochondrialaggregation patterns and activity in human oocytes andpreimplantation embryos // Ibid. – 2001. – 16. –P. 909–917.
- Wilding M., De Placido G., De Matteo L. et al. Chaoticmosaicism in human preimplantation embryos iscorrelated with a low mitochondrial membrane poten-tial // Fertil. and Steril. – 2003. – 79. – P. 340–346.
- Wilding M., Fiorentino A., De Simone M. et al. Energysubstrates, mitochondrial membrane potential andhuman preimplantation embryo division // Reprod.Biomed. Online. – 2002. – 5. – P. 39–42.
- Zjubina A., Blashkiv T., Voznesenskaya T., YanchiyR. The influence of the mitochondrial carriers inhibi-tors on murine oocyte meiotic maturation in thecumulus-oocyte-cellular complexes // Зб. тез ІІ міжнар.наук. конф. студентів та аспірантів (21–24 бер. 2006р., Львів). – Львів, 2006. – C. 451–452.
|