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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2007; 53(1): 62-76


Mesenchymal stem and progenitorcells. biological characteristicand prospects for its use.

G. T. Sukhykh, N.Y.Spivak, V.V.Malaytsev,I.M. Bogdanova, V.A. Shevchuk.

    D.K.Zabolotny Institute of microbiology and virusology,National Academy of Sciences of Ukraine, Kyiv


Abstract

Imunophenotic characteristic of the mesenchymal stem and progenitor cells, their tissue origin and functional peculiarities as well as immunological aspects of its transplantation are presented in the article. Also the address migration and the site-specific differentiation of mesenchymal stem cells its age- related and pathological process induced changes are discussed. Prospects of clinical use of mesenchymal stem cells for the treatment of degenerative arthritis, spinal cord injuries, myo- cardial infarction and other disorders are shown.

References

  1. Викторов И.В..Сухих Г.Т. Медико-биологическиеаспекты применения стволовых клеток // Вестн.РАМН. – 2002. – №4. – С. 24–30.
  2. Малайцев В.В., Богданова И.М., Сухих Г.Т. Совре-менные представления о биологии стволовой клетки //Архив патологии. – 2002. – 64. – №4. – С. 7–11.
  3. Паюшина О.В., Домарацкая Е.И., Старостин В.И.Мезенхимные стволовые клетки: источники, фено-тип и потенции к дифференцировке // Изв.РАН.Сер.биол. – 2006. – №1. – C. 6–25.
  4. Репин В.С., Сухих Г.Т. Медицинская клеточнаябиология. – М., 1998.
  5. Спивак Н.Я., Сухих Г.Т., Малайцев В.В., БогдановаИ.М. Стволовые клетки. Биология и потенциальноеклиническое использование // Трансплантологiя –2005. – 8. – №3. – С. 6–14.
  6. Сухих Г.Т., Богданова И.М., Малайцев В.В.Иммунологические аспекты трансплантации феталь-ных клеток // Бюл.эксперим.биологии и медицины. –1998. – 126 (Приложение 1). – С. 178–181.
  7. Сухих Г.Т., Малайцев В.В. Нейральная стволоваяклетка:биология и перспективы нейротрансплантации// Там же. – 2001. – 131, №3. – С. 244–255.
  8. Сухих Г.Т., Малайцев В.В., Богданова И.М. и др.Мезенхимальные стволовые клетки // Там же. – 2002.– 133, №2. – С. 125–131.
  9. 9. Фриденштейн А.Я., Лурия Е.А. Клеточные основыкроветворного микроокружения. – М.: Медицина,1980. – 200 с.
  10. 10. Щегельская Е.А., Микулинский Ю.Е., Ревищин А.В.и др. Плюрипотентность клеток стромы костногомозга и перспективы их использования в клеточнойтерапии // Онтогенез. – 2003. – 34. – №3. – С. 228–235.
  11. Alison M.R., Poulsom R., Otto W.R. et al. Recipes foradult stem cell plasticity: fusion cuisine or readymade/ J.Clin.Pathol. – 2004 – 57, №2. – P. 113–120.
  12. Barry F.P., Murphy J.M. Mesenchymal stem cells: clinicalapplications and biological characterization // I.J.Biochem.and Cell Biol. – 2004. – 36,– №4. – P. 568–584.
  13. Bartholomew A., Sturgeon C., Siatskas M. et al.Mesenchymal stem cells suppress lymphocytes pro-liferation in vitro and prolong skin graft survival invivo // Exp.Hematol. – 2002. – 30. – P. 42–48.
  14. Bennett C.N., Longo K.A., Wright W.S. et al. Regulation ofosteoblastogenesis and bone mass by Wnt10b // Proc.Natl.Acad.Sci.USA. – 2005. – 102, №9. – P. 3324–3329.
  15. Campagnoli C., Roberts I.A., Kumar S. et al. Identifi-cation of mesenchymal stem.progenitor cells in humanfirst-trimester fetal blood, liver and bone marrow //Blood. – 2001. – 98. – P. 2396–2403.
  16. Daley G., Goodell M.A., Snyder E.Y. Realistic pros-pects for stem cell therapeutics // Hematology. – 2003. –№1. – P. 398–414.
  17. Di Nicola M.,Carlo-Stella C., Magni M. et al. Humanbone marrow stromal cells suppress T-lymphocyte pro-liferation induced by cellular or non specific mitogenistimuli // Blood. – 2002. – 99. – P. 3838–3843.
  18. D,Ippolito G., Schiller P.C. The effect of aging on MSCand their potential use for therapeutic purposes //Graft. – 2000. – 3, №6. – P. 300–304.
  19. 19. Frank M.H., Sayegh M.H. Immunomodulatory functionsof mesenchymal stem cells // Lancet. – 2004. – 363,№9419. – P. 1411–1414.
  20. 20. Gershengorn M.C., Geras-Raaka E., Hardikar A.A. etal. Are better islet cell precursors generated by epithe-lial-to mesenchymal transition? // Cell Cycle. – 2005. –4, №4. – P. 380–382.
  21. Glennie S.,Soeiro I.,Dyson P.J. et al. Bone marrowmesenchymal stem cells induced division arrest anergy ofactivated T-cells // Blood. – 2005. – 105. – P. 2821–2827.
  22. Gotherstrom C., Ringden O., Tammik C. et al. Immuno-logic properties of human fetal mesenchymal stem cells //Amer. J.Obstetr.Gynecol. – 2004. – 190. – P.239–245.
  23. Gregory C.A., Gunn W.G., Reyes E. et al. How wntsignaling affects bone repair by mesenchymal stem cellsin the bone marrow // Ann.N.Y.Acad.Sci. – 2005. –1049. – P. 97–106.
  24. Horwitz E.M. Dkk-mediated expansion of adult stemcells // Trends Biotechnol. – 2004. – 22, №8. – P. 386–388.
  25. Horwitz E.M., Gordon P.L., Koo W.K.K. et al. Isolatedallogeneic bone marrow-derived mesenchymal cells engraftand stimulate growth in children with osteogenesisimperfecta: implication for cell therapy of bone //Proc.Natl.Acad.Sci.USA. – 2002. – 99, – №13. – P. 8932–8937.
  26. Huelsken J.,Behrens J. The Wnt signaling pathway //J.Cell.Sci. – 2002. – 115. – Pt.21. – P. 3977–3978.
  27. Katz A.J., Thorpady A., Thorpady S.S. et al. Cell sur-face and transcriptional characterization of human adi-pose-derived adherent stromal (hADAS) cells // StemCells. – 2005. – 23, №3. – P. 412–424.
  28. Kleber M.,Sommer L. Wnt signaling and regulation ofstem sell function // Curr.Opin.Cell.Biol. – 2004. – 16,№6. – P. 681–687.
  29. 29. Klyushnenkova E.,Mosca J.D., Zernetkina V.et al.T-cell responses to allogeneic human mesenchymal stemcells: immunogenicity, tolerance and suppression //J.Biomed.Sci. – 2005. – 12, №1. – P. 47–57.
  30. 30. Kogler G., Sensken S., Airey J.A. et al. A new humansomatic stem cell from placental cord blood with in-trinsic pluripotent differentiation potential // J.Exp.Med. – 2004. – 200, №2. – P. 123–127.
  31. Krampera M.,Glennie S.,Dyson J. et al. Bone marrowmesenchymal stem sells inhibit the response of naiveand memory antigen-specific T-cells to their cognatepeptide // Blood. – 2003. – 101. – P. 3722–3729.
  32. Kucia M., Ratajczak J., Ratajczak M.Z. Bone marrowas a source of circulating CXCR4+ tissue-commitedstem cells // Biol.Cell. – 2005. – 97, №2. – P. 133–146.
  33. Le Blanc K., Rasmusson I., Sundberg B. et al. Treat-ment of severe acute graft-versus-host disease withthird party haploidentical mesenchymal stem cells //Lancet. – 2004. – 363, №9419. – P. 1439–1441.
  34. Le Blanc K.,Tammik C.,Rosendahl K. et al. HLA ex-pression and immunologic properties of differentiatedand undifferentiated mesenchymal stem cells //Exp.Hematol. – 2003. – 31, №10. – P. 890–896.
  35. Liu L.,Girolamo C.M.,Navarro P.A. et al. Telomerasedeficiency impairs differentiation of mesenchymal stemcells // Exp.Cell.Res. – 2004. – 294, №1. – P. 1–8.
  36. Maccario R., Podmsta M., Moretta A. et al. Interac-tion of human mesenchymal stem cells with cellsinvolved in alloantigen-specific immune response fa-vors the differentiation of CD4 subsets expressing aregulatory/supressive phenotype // Haematologica. –2005. – 90, № . – P. 516–525.
  37. Minguell J.J.,Conget P.,Erices A. Biology and clinicalutilisation of mesenchymal progenitor cells // Braz.J.Med.Biol.Res. – 2000. – 33, №8. – P. 881–887.
  38. Moerman E.J., Teng K.,Lipschitz D.A. et al. Aging acti-vates adipogenic and suppresses osteogenic programs inmesenchymal marrow stroma/stem cells: role of PPAR-gamma 2 transcription factor and TGF-beta/BMP signal-ing pathways // Aging cell. – 2004. – 3, №6. – P. 379–399.
  39. 39. Rodriguez J.P.,Garat S.,Gajardo H. et al. Abnormalosteogenesis in osteoporotic patients is reflected byaltered mesenchymal stem cell dynamics // J.Cell.Biochem. – 1999. – 75, №3. – P. 414–423.
  40. 40. Romanov Y.A.,Svintsitskaya V.A.,Smirnov V.N. Searchingfor alternative sources of postnatal human mesenchymalstem cells: candidate MSC-like cells from umbilical cord // Stem.Cells. – 2003. – 21, №1. – P. 105–110.
  41. Song L., Baksh D., Tuan R.S. Mesenchymal stem cell-based cartilage tissue engineering: cells, scaffold andbiology // Cytotherapy. – 2004. – 6, №6. – P. 596–601.
  42. Stauer B.E., Brehm M., Zeus T. et al. Repair of infarctedmyocardium by autologous intracoronary mononuclearbone marrow cell transplantation in human // Circula-tion. – 2002. – 106. – P. 1913–1918.
  43. Tang Y.L.,Zhao Q., Zhang Y.C. et al. Autologousmesenchymal stem cell transplantation induce VEGFand neovascularization in ischemic myocardium //Regulatore pеptides. – 2004. – 117, №1. – P. 3–10.
  44. Yang L.Y., Zheng J.K., Wang C.Y. et al. Stromal cellsfrom human Wharton,s Jely differentiate into neuronalcells // Sichuan Da Xue Xue Bao Yi Xue Ban. –2005. –36, №1. – P. 13–16.
  45. Yen B.L.,Huang H., I., Chen C.С. et al. Isolation ofmultipotent cells from human term placenta.// Stem.Cells. – 2005. – 23, №1. – P. 3–9.
  46. Zhou S.,Zilberman Y.,Wassermann K. et al. Estrogenmodulates estrogen receptor alpha and beta expression,osteogenic activity and apoptosis in mesenchymal stemcells (MSCs) of osteoporotic mice // J.Cell.Biochem. –2001. – Suppl. 36. – P. 144–155.

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