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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2007; 53(1): 11-15


The role of the ovarian steroidaromatase in pathogenesisof reproductive cycles disorders

L.V. Tarasenko, A.G. Reznikov.

    Institute of Endocrinology and Metabolism named afterV.P.Komisarenko, AMS of Ukraine, Kyiv


Abstract

In the rats with regular estrous cycles effects of letrozole, a steroid aromatase inhibitor, on the enzyme activity in ovarian tissues and reproductive system condition were studied. Letrozole was administered per os daily in a dose of 1 mg/kg b.w. over 10 days. As the result of treatment, 20.5-fold de- crease in aromatase activity was obtained. All animals have developed persistent anestrus with vaginal smear patterns being similar to diestrus. Uterine weights were two-fold less than that of controls, and ovarian weights increased by one third. The ovaries contained multiple cystoidal follicles. Results of the study demonstrate the key role of ovarian steroid aromatase in letrozole-induced disorders of reproductive cycles. Letrozole might be recommended for experimental modeling of reproductive cycle disorders in female rats.

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