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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2006; 52(6): 71-78


Molecular mechanisms of plant proanthocyanidins cytoprotective actionon gastric lesions of different genesis

O.S.Zayachkivska.

    Lviv National Medical University named after D. Galytskyi,Lviv, Ukraine.


Abstract

The molecular defence mechanisms against ethanol- and stress- induced (WRS) gastric lesions under the action of plant 87ISSN 0201-8489 Фізіол. журн., 2006, Т. 52, № 6 proanthocyanidins from grapefruit-seed extract (GSE) were investigated. Pre-treatment with GSE (8-64 mg/kg/day) in dose- dependent manner attenuated gastric lesions induced by 100% ethanol and WRS; the doses of GCE reducing these lesions by 50% (ID50) were 28 and 36 mg/kg/day, respectively and this protective effect was similar to that obtained with PGE2 ana- logue. Lesions reduction was also accompanied by improve- ment of gastric blood flow, antiradical action, increased mu- cosal generation of PGE2, antioxidant activity.

References

  1. Гжегоцький М.Р., Заячківська О.С. Роль капсаїцин- чутливих сенсорних нервів та оксид азоту у гастропротекції, індукованій екстрактом насіння амаранту // Експерим. і клін. фізіологія та біохімія. – 2004. – 4. – C.92–95.
  2. Зиновьева В.Н., Спасов А.А. ДНК-протекторная активность природных и синтетических антиокси- дантов. – Биомед. химия. – 2004. – 50 (3). – С.231–242.
  3. Заячківська О.С. Вплив кальцитонінгенспро- рідненого пептиду на гастропротекцію, індуковану екстрактом грейпфрута // Експерим. і клін. фізіологія та біохімія. – 2005. – 4. – С. 44–49.
  4. Cагач В.Ф., Присяжна О.Д., Ткаченко М.М., Коцю- руба А.В. Вплив L-аргініну на функціональну активність ендотелію за умов експериментального цукрового діабету // Фізіол. журн. – 2005. – 51, № 2. – С.3–7.
  5. Ariga T. The antioxidative function, preventive action on disease and utilization of proanthocyanidins // Biofactors. – 2004. – 21(1–4). – P.197–201.
  6. Beil W., Birkholz C., Sewing K.F. Effects of flavonoids on parietal cell acid secretion, gastric mucosal prostag-landin production and Helicobacter pylori growth //rzneimittelforschung. – 1995. – 45. – Р. 697–700.
  7. Blankson H., Grotterod E.M., Seglen P.O. Prevention of toxin induced cytoskeletal disruption and apoptotic liver cell death by the grapefruit flavonoid, naringin // Cell Death Differ. – 2000. – 7. – P.739–746.
  8. Dembinski A., Warzecha Z., Ceranowicz P. et al. Role of capsaicin-sensitive nerves and histamine H1, H2, and H3 receptors in the gastroprotective effect of hista- mine against stress ulcers in rats // Eur. J. Pharmacol. – 2005. – 31; 508 (1–3). – P.211–221.
  9. 9. Dixon R.A., Xie D.Y., Sharma S.B. Proanthocyanidins- a final frontier in flavonoid research? // New Phytol. – 2005. – 165(1). – P.9–28.
  10. 10. Folts J.D. Potential health benefits from the flavonoids in grape products on vascular disease // Adv. Exp. Med. Biol. – 2002. – 505. – P. 95–111.
  11. Gorinstein S., Caspi A., Libman I. et al. Red Grape- fruit Positively Influences Serum Triglyceride Level in Patients Suffering from Coronary Atherosclerosis: Studies in Vitro and in Humans // J. Agric. Food Chem. –2006. – 54 (5). – Р. 1887–1892.
  12. Heggers J.P., Cottingham J., Gusman J. et al. The effec- tiveness of processed grapefruit-seed extract as an anti- bacterial agent: II. Mechanism of action and in vitro tox- icity // J. Altern. Compl. Med. – 2002. – 8. – P. 333–340.
  13. Iwasaki Y., Matsui T., Arakawa Y. The protective and hormonal effects of proanthocyanidin against gastric mucosal injury in Wistar rats // J. Gastroenterol. – 2004. – 39(9). – P.831–837.
  14. Kanno S., Shouji A., Asou K., Ishikawa M. Effects of naringin on hydrogen peroxide-induced cytotoxicity and apoptosis in P388 cells // J. Pharmacol. Sci. – 2003. – 92. – P.166–170.
  15. Konturek S.J., Drozdowicz D., Konturek P.C. et al. Gastroprotective effects of flavonoids in plant extracts // J. Physiol. and Рharmacol. – 2005. – 56 (1). – P.219–231.
  16. Kwiecien S., Brzozowski T., Konturek P.C. et al. The role of reactive oxygen species and capsaicin-sensitive sensory nerves in the pathomechanisms of gastric ulcers induced by stress // Ibid. – 2003. – 54. – P. 423–437.
  17. Leitao D.P., Polizello A.C., Ito I.Y., Spadaro A.C. An- tibacterial screening of anthocyanic and proanthocyanic fractions from cranberry juice // J. Med. Food. – 2005. – 8(1). – P.36–40.
  18. Proteggente A.R., Pannala A.S., Paganga G. et al. The antioxidant activity of regularly consumed fruit and vegetables reflects their phenolic and vitamin C com- position // Free Radic Res. – 2002. – 36. – P. 217–233.
  19. 19. Reagor L., Gusman J., McCoy L. et al. The effective- ness of processed grapefruit-seed extract as an anti- bacterial agent: I. An in vitro agar assay // J. Altern. Complement Med. – 2002. – 8. – P.325–332.
  20. 20. Tirillini B. Grapefruit: the last decade acquisitions // Fitoterapia. – 2000. – 71(l). – P.S29–S37.

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