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Molecular mechanisms of plant proanthocyanidins cytoprotective actionon gastric lesions of different genesis
O.S.Zayachkivska.
Lviv National Medical University named after D. Galytskyi,Lviv, Ukraine.
Abstract
The molecular defence mechanisms against ethanol- and stress-
induced (WRS) gastric lesions under the action of plant
87ISSN 0201-8489 Фізіол. журн., 2006, Т. 52, № 6
proanthocyanidins from grapefruit-seed extract (GSE) were
investigated. Pre-treatment with GSE (8-64 mg/kg/day) in dose-
dependent manner attenuated gastric lesions induced by 100%
ethanol and WRS; the doses of GCE reducing these lesions by
50% (ID50) were 28 and 36 mg/kg/day, respectively and this
protective effect was similar to that obtained with PGE2 ana-
logue. Lesions reduction was also accompanied by improve-
ment of gastric blood flow, antiradical action, increased mu-
cosal generation of PGE2, antioxidant activity.
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