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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2006; 52(6): 71-78


Molecular mechanisms of plant proanthocyanidins cytoprotective actionon gastric lesions of different genesis

O.S.Zayachkivska.

    Lviv National Medical University named after D. Galytskyi,Lviv, Ukraine.



Abstract

The molecular defence mechanisms against ethanol- and stress- induced (WRS) gastric lesions under the action of plant 87ISSN 0201-8489 Фізіол. журн., 2006, Т. 52, № 6 proanthocyanidins from grapefruit-seed extract (GSE) were investigated. Pre-treatment with GSE (8-64 mg/kg/day) in dose- dependent manner attenuated gastric lesions induced by 100% ethanol and WRS; the doses of GCE reducing these lesions by 50% (ID50) were 28 and 36 mg/kg/day, respectively and this protective effect was similar to that obtained with PGE2 ana- logue. Lesions reduction was also accompanied by improve- ment of gastric blood flow, antiradical action, increased mu- cosal generation of PGE2, antioxidant activity.

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