Effects of changesin mitochondrial permeability transition of medullary cardiovascular neuronson circulation in rats
L.N.Shapoval, L.S.Pobegailo, O.V.Dmytrenko, L.G.Stepanenko, V.F.Sagach
Bogomoletz Institute of Physiology, Kyiv, Ukraine.
Abstract
In acute experiments on anaesthetized with urethane
normotensive rats we studied effects of modulating the mito-
chondrial permeability transition (MPT) of the neurons in
the medullary cardiovascular nuclei – nucleus of the tractus
solitarius (NTS), paramedian reticular nucleus (PMn),
n.ambiguus (AMB), and lateral reticular nucleus (LRN) on
the systemic arterial pressure level (SAP). An increase in the
MPT with injections of an inductor for MPT phenylarsine
oxide (10 –12 М - 10 –8 М) into the medullary nuclei under
exploration has been shown to induce the lowering in the
SAP level in a dose-dependent manner. A decrease in the
MPT of the medullary neurons with either cyclosporine A or
melatonin (10 –12 М - 10 –10 М) resulted in hypertensive
responses of the SAP. Effects of phenylarsine oxide injec-
tions into the medullary nuclei were attenuated after prelimi-
nary intravenous administration of L-arginine. The data ob-
tained give evidence that functional activity of the medullary
cardiovascular neurons and their effects depend to a large
extent on the functional state of their mitochondria.
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