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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2006; 52(6): 15-24

Effects of changesin mitochondrial permeability transition of medullary cardiovascular neuronson circulation in rats

L.N.Shapoval, L.S.Pobegailo, O.V.Dmytrenko, L.G.Stepanenko, V.F.Sagach

    Bogomoletz Institute of Physiology, Kyiv, Ukraine.



Abstract

In acute experiments on anaesthetized with urethane normotensive rats we studied effects of modulating the mito- chondrial permeability transition (MPT) of the neurons in the medullary cardiovascular nuclei – nucleus of the tractus solitarius (NTS), paramedian reticular nucleus (PMn), n.ambiguus (AMB), and lateral reticular nucleus (LRN) on the systemic arterial pressure level (SAP). An increase in the MPT with injections of an inductor for MPT phenylarsine oxide (10 –12 М - 10 –8 М) into the medullary nuclei under exploration has been shown to induce the lowering in the SAP level in a dose-dependent manner. A decrease in the MPT of the medullary neurons with either cyclosporine A or melatonin (10 –12 М - 10 –10 М) resulted in hypertensive responses of the SAP. Effects of phenylarsine oxide injec- tions into the medullary nuclei were attenuated after prelimi- nary intravenous administration of L-arginine. The data ob- tained give evidence that functional activity of the medullary cardiovascular neurons and their effects depend to a large extent on the functional state of their mitochondria.

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