Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2006; 52(3): 42-51

The role of short chain fatty acids and lactic acidin regulation of gastric secretion

T.V. Вeregova, T.M. Falalyeyeva

    Kyiv National Shevchenko University, Pharmaco-physiologydepartment



Abstract

The investigation was carried out in acute experiments by means of isolated stomach perfusion by Ghosh and Shild and in chronic experiments in dogs with fistula of the stomach and duodenum. In rats with intact nervous system lactulose as the source of short chain fatty acids (SCFAs) diminished basal and stimulated by insulin, pentagastrin and histamine gastric acid secretion. By contrast it did not influence carbachol gas- tric acid secretion. In dogs with intact nervous system lactulose also suppressed the intensity, debit of acid and pepsin of gastric juice stimulated by insulin and histamine. It suggests that the effect of lactulose does not dependent on kinds of animals. Truncal vagotomy removed the inhibitory action of lactulose on pentagastrin and histamine gastric acid secretion in rats. SCFAs and lactic acid suppressed pentagastrin gastric acid secretion in rats. Lactulose, propionate potassium, lac- tate potassium enhanced the blood glucose level. Truncal vago- tomy did not influence the increase of the blood glucose level evoked by lactulose. It is concluded that SCFAs decreases gastric secretion in the third intestinal phase through central inhibition. The mechanism of inhibitory action of lactic and propionic acids depends on their role in the liver gluconeogen- esis which leads to increase of the blood glucose level. Hyper- glycemia as it is known suppress gastric secretion through diminishing of neural cholinergic activity of nerves vagus.

Full text: (PDF, in Ukrainian)

References

  1. Берегова Т.В. Роль блукаючих нервів в централь- ному гальмуванні шлункової секреції: Автореф. дис. ... д-ра біол. наук – К., 2001. – 35 с.
  2. Гройсман С.Д., Береговая Т.В., Черпак Б.Д. Новые аспекты возможного использования нормазе // Материалы симпозиума “Применение нормазе в клинике внутренних болезней”. – К., 1993. – С.1–6. Т.В. Берегова, Т.М. Фалалєєва
  3. 05ISSN 0201-8489 Фізіол. журн., 2006, Т. 52, № 3 Значення коротколанцюгових жирних кислот
  4. Гройсман С.Д., Губкин В.А., Береговая Т.В. Полу- автоматическая электротитрометрическая установ- ка для титрования желудочного сока // Лаб. дело. – 1988. – № 9. – C.66–67.
  5. Губська О.Ю. Застосування лактулози у комплекс- ній терапії виразкової хвороби із супутніми хронічними захворюваннями печінки // Фармакол.вісн. – 1996. – № 5. – С.22–23.
  6. Зайцева Е.И., Аксенов О.С., Миргородская Л.Н., Молчанов В.В. Новые аспекты клинического применения препарата нормазе. – В кн.: Спорные, противоречивые и не решенные вопросы в гастро-энтерологии. Обоснование клинического использо-вания препарата нормазе: Тез докл. – Смоленск-Москва, 1993. – С.469–476.
  7. Кухарский В.М., Береговая Т.В, Харченко Н.М., Гройсман С.Д. О механизме противоязвенного действия нормазе // Рос. журн. гастроэнтерологии, гепатологии, колопроктологии. – 1996. – № 4. –С.236–239.
  8. Матросова Е.М., Беркос О.В., Самохвалов В.И. О кишечной фазе желудочной секреции // Физиол. журн. им. И.М. Сеченова. – 1973. – № 7. – С.1064–1073.
  9. Cкляров О.Я., Косий Є.Р., Скляров Є.Я. Фізіоло- гічні та клінічні основи гастроентерології. – Львів: Навч.-вироб. майстерні Львів. поліграф. технікуму,1997. – 335 с.
  10. 9. Передерій В.Г., Миронова К.О., Бичкова Н.Г. тa ін. Вивчення терапевтичної дії нормазе у хворих на виразкову хворобу шлунку та дванадцятипалої кишки з супутніми колодискинезіями. – У кн.: Матеріали першого національного з’їзду фармако- логів України “Сучасні проблеми фармакології”. –Полтава, 1995. – С.127–128.
  11. 10. Шалимов С.А., Радзиховский А.П., Кейсевич Л.В. Руководство по экспериментальной хирургии. – М.: Медицина, 1989. – 272 с.
  12. Aiello R.J., Armentano L.E. Effect of volatile fatty acids on propionate metabolism and gluconeogenesis in caprine hepatocytes // J. Dairy Sci. – 1987. – 70,№ 12. – P.2504–2510.
  13. Alamowitch C., Boillot J., Boussairi A. Lack of effect of an acute ileal perfusion of short-chain fatty acids on glucose metabolism in healthy men // Amer. J. Physiol. –1996. – 71. – P.199–204.
  14. Anderson J.W., Bridges S.R. Short-chain fatty acids fermentation products of plant fiber affect glucose metabolism of isolated rat hepatocytes // Proc. Soc. Exp. Biol. Med. – 1984. – 177, № 2. – P.372–376.
  15. Armentano L.E. Ruminant hepatic metabolism of vola- tile fatty acids, lactate and pyruvate // J. Nutr. – 1992. –122, № 3. – P.838–842.
  16. Ballongue J., Schumann C., Quignon P. Effects of lactulose and lactitol on colonic microflora and enzymatic activity // Scand. J. Gastroenterol. – 1997. – 32. – P.41–44.
  17. Beregova T.V., Kucharskij V.M., Mirgorodskaya L.N. et al. The short chain fatty acids the possible cause of lactulose antiulcer action // Dig. Dis. Sci. – 1997. – 42,№ 1. – P.206.
  18. Campieri M., Gionchetti P. Bacteria as the cause of ulcerative colitis // Gut. – 2001. - 48. – P.132–135.
  19. Cherbut C, Aube AC, Blottiere HM, Galmiche JP. Ef- fects of short-chain fatty acids on gastrointestinal motil- ity // Scand. J. Gastroenterol. – 1997. – 222. – P.58–61.
  20. 19. Cuche G., Cuber J.C., Malbert C.H. Ileal short chain fatty acids inhibit gastric motility by a humoral path- way // Amer. J. Physiol. Gastrointest. Liver Physiol. –2000. – 279. – P.925–930.
  21. 20. Cummings J.H., Bingham S.A., Heaton K.W. et al. Fe- cal weight, colon cancer risk, and dietary intake of nonstarch polysaccharides (dietary fiber) // Gastroen-terology. – 1992. – 103. – P.1783–1789.
  22. Cummings J.H., Englist H.N. Measurement of starch fermentation in the human large intestine // Can. J. Physiol. Pharmacol. – 1991. – 69. – P.121–129.
  23. Evans R.C., Fear S., Ashby D. et al. Diet and colorectal cancer: an investigation of the lectin/galactose hypothesis // Gastroenterology. – 2002. – 122, № 7 – P.1784–1792.
  24. Fuchs C.S., Giovannucci E.L., Colditz G.A. et al. Di-etary fiber and the risk of colorectal cancer and adenoma in women // N. Engl. J. Med. – 1999. – 340. – P.169–176.
  25. Ghosh M.H., Shild H.O. Continuous recording of acid gastric secretion in the rat // Br. J. Pharmac. Chemother. – 1958. – 13. – P.54–61.
  26. Gibson G.R., Fuller R. Aspects of in vitro and in vivo research approaches directed toward identifying probiotics and prebiotics for human use // J. Nutr. –2000. – 130. – P.391–395.
  27. Hara I., Miyake H., Hara S. et al. Sodium butyrate induces apoptosis in human renal cell carcioma cells and synergistically enhances their sensitivity to anti- fas-mediated cytotoxicity // Int. J. Oncol. –2000. – 17,№ 6. – P.1213–1218.
  28. Hunt G.N. Method for estimating peptic activity in gastric contents // Biohem. J. – 1948. – 42. – P.104–109.
  29. Johnson L.R., Grossman M.I. Jacobson E.D., Schultz S.G. Physiology of gastrointestinal tract. – New York: Raven Press, 1981. – 1492 p.
  30. 29. Lam W.F., Masclee A.A.M., Muller E.S.M. et al. Ef- fect of hyperglycemia on gastric acid secretion during the gastric phase of digestion // Amer. J. Physiol. –1997. – 272. – P.1116–1121.
  31. 30. Laurent C., Simoneau C., Marks et al. Effect of acetate and propionate on fasting hepatic glucose production in humans // Eur. J. Clin. Nutr. – 1995. – 49, № 7. –P.484–491.
  32. Mortensen F.V., Nielsen H., Mulvany M.J., Hessov I. Short chain fatty acids dilate isolated human colonic resistance arteries // Gut. – 1990. – 31. - P.1391–1394.
  33. Olsen P.S., Pedersen J.H., Kirkegaard P. et al. Neurotensin indused inhibition of gastric acid secretion in duodenal ulcer
  34. ISSN 0201-8489 Фізіол. журн., 2006, Т. 52, № 3 51patients before and after parietal cell vagotomy // Gut. –1984. – 25, № 5. – P. 481–484.
  35. Scheppach W., Christl S.U., Bartram H.P., Richter F., Kasper H. Effect of short-chain fatty acids on the inflamed colonic mucosa // Scand. J. Gastroenterol. –1997. – 32 – P.53–57.
  36. Schubert M.L. Gastric secretion // Curr. Opin. Gastroenterol. – 2002. – 18, № 16. – P.639–649.
  37. Tache Y., Raybould H., Wei J.Y. Central and peripheral actions of calcitonin gene-related peptide on gastric secretory and motor function // Adv. Exp. Med. Biol. –1991. – 298. – P.183–198.
  38. Topping D.L., Clifton P.M. Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides // Physiol. Rev. – 2001. – 81, № 3. – P.1031–1064.
  39. Tuohy K.M., Zimer C.J., Klinder A. et al. A human volunteer study to determine the prebiotic effect of lactulose powder on human colonic microbiota // Microb. Ecol. Health and Dis. – 2002. – 14. – P.165–173.
  40. Zai H., Haga N., Fujino M.A., Itoh Z. Effect of pep- tide YY on gastric motor and secretory activity in va- gally innervated and denervated corpus pouch dogs //Regul. Pept. – 1996. – 61, № 3 – P.181–188.
© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.