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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2006; 52(3): 42-51


The role of short chain fatty acids and lactic acidin regulation of gastric secretion

T.V. Вeregova, T.M. Falalyeyeva

    Kyiv National Shevchenko University, Pharmaco-physiologydepartment


Abstract

The investigation was carried out in acute experiments by means of isolated stomach perfusion by Ghosh and Shild and in chronic experiments in dogs with fistula of the stomach and duodenum. In rats with intact nervous system lactulose as the source of short chain fatty acids (SCFAs) diminished basal and stimulated by insulin, pentagastrin and histamine gastric acid secretion. By contrast it did not influence carbachol gas- tric acid secretion. In dogs with intact nervous system lactulose also suppressed the intensity, debit of acid and pepsin of gastric juice stimulated by insulin and histamine. It suggests that the effect of lactulose does not dependent on kinds of animals. Truncal vagotomy removed the inhibitory action of lactulose on pentagastrin and histamine gastric acid secretion in rats. SCFAs and lactic acid suppressed pentagastrin gastric acid secretion in rats. Lactulose, propionate potassium, lac- tate potassium enhanced the blood glucose level. Truncal vago- tomy did not influence the increase of the blood glucose level evoked by lactulose. It is concluded that SCFAs decreases gastric secretion in the third intestinal phase through central inhibition. The mechanism of inhibitory action of lactic and propionic acids depends on their role in the liver gluconeogen- esis which leads to increase of the blood glucose level. Hyper- glycemia as it is known suppress gastric secretion through diminishing of neural cholinergic activity of nerves vagus.

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