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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2006; 52(3): 34-41


Electrogenicity of Na+,K+ ATPase in endothelial cells

A.I. Bondarenko, V.F. Sagach

    O.O. Bogomoletz Institute of Physiology, Kyiv, Ukraine


Abstract

The role of Na pump in the regulation of the membrane poten- tial of endothelial cells of rat isolated aorta at rest and during stimulation by acetylcholine was investigated. Inhibition of Na pump by 500 mcM ouabain and potassium-free solution depolarized endothelial cells by 11 mV. Na pump reactivation caused by potassium restoration hyperpolarized endothelium by 18 mV, this hyperpolarization was sensitive to 500 mcM ouabain. Potassium-free solution and ouabain attenuated the duration of the acetylcholine-evoked hyperpolarization. The results presented demonstrate that the sustained hyperpolar- ization of endothelial cells to acetylcholine in rat aorta may be partially mediated by Na pump stimulation.

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