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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2006; 52(1): 101-105


Investigation of macromolecules permeability through the mouth cavitymucous on hamster’s cheek pouches

P.L. Starokadomskyy

    Institute of Molecular Biology and Genetics, NationalAcademy of Sciences of Ukraine, Kyiv, Ukraine


Abstract

The technique of permeability assessment for high-molecular compounds is presented in present work. Isolated hamster cheek pouches as a simple and convenient model for the trans- port studies were used. It was shown that a mucous membrane is permeable for ?-interferon, insulin but not for nucleic acids and peroxidase. Buccal permeability for insulin is provided by its transport through the intercellular ways. Data obtained in experiments with use of rodent keratinized mucous membrane could not be directly extrapolated to human buccal mucous permeability due to significant differences in the nature and organization of intercellular lipids in these species. However, we supposed that freshly isolated hamster cheek pouch could be employed as initial step of assessment for the fast screen- ing of buccal permeability for the high-molecular compounds.

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