The influence of percutaneous magnetolazer irradiation of the blood and liver on the bile secretion, general bilirubin excretion and its fractions, cholesterol and bile acids rate was studied experimentally on male rats. A lazer generator «Luch-2» with a magnetic nozzle (wave-length 0,82 mm, power density 0,178 W*cm^–2, magnetic field tension 30–35 mT, the cource ѕ 2 daily procedures) was used. Bile secretion intensity was noted to depend on the dose. Maximal bile secretion and its basic components were observed during the liver irrigation with an exposition for 120 s and blood ones with an exposition for 240 s respectively. Bile secretion rate was higher during magnetolazer influence on the blood. Liver irrigation was assotiated with an increased secretion of the conjugated bilirubin. Thus, there are various stimulant mechanisms of the liver function activity in the course of magnetolazer influence on the liver and blood