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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2005; 51(2): 86-89


Features of operated nerveregeneration under decompensatedform of diabetes

O.O. Goncharuk

    A.P. Romodanov Institute Neurosurgery AMS of Ukraine, Kyiv


Abstract

Work is devoted to a problem of the influence of diabetes on nervous system function, in particular, the regeneration of peripheral nerves. Chronic experiment were carried out on 8 mini-pigs (weight 35-40 kg) in two stages. Absolute insulin insufficiency was formed by total pancreatomy (the first stage); on the same day the sciatic nerve of an animal was severed 5- 6 sm above its branching and sewed by perineural seam (the second stage). 60 days after neurorrhaphy a seam zone with the adjacent tissues was dissected for the investigation of morphological macro- and microscopic features of proximal and distal stump in the operated sciatic nerve, regenerative neuroma, micro-circulating channel of a nerve, a connecting tissue of neural anastomosis and a nerve trunk as well as a level of synaptogenesis and a condition of separate muscles innervated by the operated nerve. The blood level of glucose and other biochemical parameters were assessed every three days. Macro- and microscopic examination testifies that the restoration of the operated nerve by sewing together of its ends under the decompensated diabetes, is considerably at- tenuated and is practically impossible during the late stages.

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© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2018.