Heart rate variabiity analysis as ameasure of baroreflex sensitivity
I.A. Khripachenko, A.V. Savustyanenko,L.A. Kedenko, I.I. Zinkovych
Donetsk Medical University

Abstract
Spectral analysis of the heart rate variability can be used as a
measure of baroreflex sensitivity in ketamine anesthetized
rats. Stimulation of б1-receptors with phenylephrine (0,01
mg/kg, i.v.) results in a rise of the strength of heart rate
regulation, principally in the low frequency band. Maximal
deviations of spectral indexes from basal level were observed
on 4 – 8 min for low (0,2 – 1 Hz) and high (1 – 3 Hz)
frequencies bands and on 10 – 15 min for very low (0,08 – 0,2
Hz) frequency band after phenylephrine injection
References
- Гаврилова С.А., Демидов Л.В., Медведева Н.А., АшмаринИ.П. Хроническое введение интерферона-альфа снижаетартериальное давление и ЧСС у крыс // Бюл. эксперим.биологии и медицины. – 2000. – 129, № 5. – С. 491–495.
- Зинкович И.И., Хрипаченко И.А. Спектральныйанализ вариабельности сердечного ритма наркотизи-рованной крысы: требования к продолжительностирегистрируемого кардиосигнала // Питання експе-рим. та клін. Медицини. – 2003. – 7, № 1. – С. 25–27.
- Применение математических методов в иссле-дованиях по физиологии человека / Под ред.В.Н.Казакова. – Донецк, 2000. – 84 с.
- Яблучанский Н.И., Мартыненко А.В., Исаева А.С.Основы практического применения технологиивариабельности кровообращения. – Харьков:Основа, 2000. – 112 с.
- Akine A., Suzuka H., Hayashida Y., Kato Y. Effects ofketamine and propofol on autonomic cardiovascularfunction in chronically instrumented rats // Auton.Neurosci. – 2001. – 87, № 2–3. – P. 201–208.
- Bertram D., Barr’es C., Cuisinaud G., Julien C. Thearterial baroreceptor reflex of the rat exhibits positivefeedback properties at the frequency of Mayer waves// J. Physiol. – 1998. – 513, № 1. – P. 251–261.
- Blaber A.P., Bondar R.L., Kassam M.S. Heart rate variabil-ity and short duration spaceflight: relationship to post-flightorthostatic intolerance // BMC Physiology. – 2004. – 4, № 6.
- Blasi A., Jo J., Valladares E., Morgan B.J. et al. Car-diovascular variability following arousal from sleep:Time-varying spectral analysis // J. Appl. Physiol. –2003. – 95, June. – P. 1394 – 1404.
- 9. Conci F., Rienzo M.D., Castiglioni P. Blood pressure andheart rate variability and baroreflex sensitivity before andafter brain death // J. Neurol. Neurosurg. Psychiatry. –2001. – 71. – P. 621–631.
- 10. Di Rienzo M., Castiglioni P., Parati G. Effects of sino–aorticdenervation on spectral characteristics of blood pressureand pulse interval variability: a wide-band approach // Med.Biol. Eng. Comput. – 1996. – 34, № 2. – P. 133–141.
- Frazier S.K., Moser D.K., Stone K.S. Heart rate variabil-ity and hemodynamic alterations in canines with normalcardiac function during exposure to pressure support,continuous positive airway pressure, and a combinationof pressure support and continuous positive airway pres-sure // Biol. Res. Nurs. – 2001. – 2, № 3. – P. 167–174.
- Gamero L.G., Vila J., Palacios F. Wavelet transform analysisof heart rate variability during myocardial ischaemia //Med. Biol. Eng. Comput. – 2002. – 40, № 1. – P. 72–78.
- Gomes M.E., Souza A.V., Guimaraes H.N., Aguirre L.A.Investigation of determinism in heart rate variability //Chaos. – 2000. – 10, № 2. – P. 398–410.
- Heusser K., Vitkovsky J., Schmieder R.E., Schobel H.P.AT1 antagonism by eprosartan lowers heart ratevariability and baroreflex gain // Auton. Neurosci. – 2003. –107, № 1. – P. 45–51.
- Hoffmann J., Grimm W., Menz V. et al. Heart rate vari-ability and baroreflex sensitivity in idiopathic dilated car-diomyopathy // Heart. – 2000. – 83, № 5. – P. 531–538.
- Kuusela T.A., Kaila T.J., Kahonen M. Fine structureof the low-frequency spectra of heart rate and bloodpressure // BMC Physiology. – 2003. – 3, № 11.
- Li L., Zhu J.W., Cao Y.X., Li P. Effect of activities of vagisympathetic nervous system on heart rate variability// Sheng Li Xue Bao. – 1998. – 50, № 5. – P. 519–524.
- Mainardi L.T., Bianchi A.M., Cerutti S. Time-fre-quency and time-varying analysis for assessing thedynamic responses of cardiovascular control // Crit.Rev. Biomed. Eng. – 2002. – 30, № 1–3. – P. 175–217.
- 19. Opthof T., Coronel R., Rademaker H.M. et al. Changesin sinus node function in a rabbit model of heart failurewith ventricular arrhythmias and sudden death // Cir-culation. – 2000. – 101, № 25. – P. 2975–2980.
- 20. Souza N.E.P., Neidecker J., Lehot J.J. To understandblood pressure and heart rate variability // Ann. Fr.Anesth. Reanim. – 2003. – 22, № 5. – P. 425–452.
- Task force of the European society of cardiology and thenorth American society of pacing and electrophysiology.Standards of Measurements, physiological interpretationand clinical use // Circulation. – 1996. – 93. – P. 1043–1065.
- Ueno L.M., Moritani T. Effects of long-term exercisetraining on cardiac autonomic nervous activities andbaroreflex sensitivity // Eur. J. Appl. Physiol. – 2003. –89, № 2. – P. 109–114.
|