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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2005; 51(1): 109-120

Atp-sensitive potassium channels:classification, structureand functions

M.A. Mohort, I.V.Samarskaya

    Institute Pharmacology and Toxicology, Academy of MedicalSciences, Kyiv



Abstract

The review is dedicated to classification, structure and func- tion of ATP-sensitive potassium channels. А general classification of K+ channels into families is based upon the primary amino acid sequence of the pore-forming subunits. The earliest classification of potassium channels was made according to the main mechanism of activation or opening of the channels. Activation of the voltage-sensitive channels is regulated by changes in the membrane potential, and of the ligand-sensitive channels by a number of ligands (calcium ions, ATP, neurotransmitters and G-protein).

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