The effects of omega-3 polyunsaturatedfatty acids on lipid peroxidation
T. Kukoba, A.Shysh, A.A. Moibenko, A. Kotsjuruba, O. Kharchenko
A.A. Bogomoletz Institute of Physiology National Academy ofSciences of Ukraine, Kyiv
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Abstract
The aim of this study was to evaluate the effects of a diet
supplemented with omega-3 polyunsaturated fatty acids
(PUFAs) (plant-derived a-linolenic acid and eicosapentaenoic
and docosahexaenoic acids with ?-tocopherol (product
«Tekom»)) on the myocardial phospholipid fatty acids
composition, lipid peroxidation and activity antioxidant
enzymes – superoxide dismutase and catalase in myocardial
tissue in control and after ischemia/reperfusion of isolated
working rat hearts. Inclusion of omega-3 PUFAs into the
animals’ diet within 4 weeks demonstrated that a-linolenic
acid and “Tekom” increased omega-3 polyunsaturated fatty
acids content in cardiomyocytes membranes and limited lipid
peroxidation (decreased content of congugates of dienes and
malone dialdehyde, reduced hemiluminescence of myocardial
tissue). Additionally omega-3 PUFAs caused the beneficial
effects on activity of antioxidant enzymes in cardiac tissue
(increased superoxide dismutase and catalase activity).
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