Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2004; 50(6): 95-100

Mechanisms of efficiency of adaptation to hypoxia at primary hypothyroidism

M.P. Radzievskaya

    Boris Grinchenko Kyiv municipal pedagogical university.



Abstract

The paper contains data concerning the stimulatory effect of subcompensated hypoxia on the function of thyroid gland. Hypoxia-mediated improvement of the state of functional respiratory system (FRS) affects the endocrine system that is a part of the regulatory chain of FRS. Compensation of hypoxic state that takes place in pathogenesis of thyroid gland hypofunction is the result of improved oxygen supply during adaptation to hypoxia. Optimisation of oxygen supply as the result of the improvement of FRS working organs leads to the increase in velocity of oxygen consumption by organism and can evidence about the increase of oxygen consumption by thyroid glands that promotes their secretory activity intensification.

Full text: (PDF, in Ukrainian)

References

  1. Болезни щитовидной железы / Под ред. Е.М. Бравермана. – М.: Медицина, 2000. – 417 с.
  2. Васильев В.А. Функция желез внутренней секреции при гипоксии. – М.–Л.: Медицина, 1974. – 145 с.
  3. Колчинская А.З. Хацуков Б.Х., Закусило М.П. Кислородная недостаточность, деструктивное и контструктивное действие. – Нальчик, 1999. – 239 с.
  4. Ткачук В.А. Введение в молекулярную эндокри- нологию. – М.: Медицина, 1989. – 203 с.
  5. Эндокринология. Пер. с англ. / Под ред. Н.Лавина. – М.: Практика, 1999. –128 с.
  6. Narayan G. Metabolism of tissues excised from thy- roxine-injected rats // Appl. Endocrinol. – 1984. – P. 64. – P. 735.
  7. Roth T.D. Physiological mechanisms controlling en- docrine function // Appl. Physiol. – 1991. – №14. – P. 405–408.
  8. Semenza G.L., Wang GL. Characterization of hypoxia- inducible factor 1 and regulation of DNA binding ac- tivity by hypoxia // Biol. Chem. – 1993. – 268, № 29. – P. 21513–21518.
  9. 9. Semenza G.L. HIF-1: mediator of physiological and pathophysiological responses to hypoxia // J. Appl. Physiol. – 2000. – 88. – Р. 1474–1480.
  10. 10. Tepperman G., Tepperman H. Mеtabolic and endo- crine physiology. – Chicago-London, 1987. – 656 p.

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2025.