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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2004; 50(6): 88-94


The effect of low dose-rate a-radiation on cellular contentof the chronic inflammatory focus

N.A. Klimenko, N.I. Onishchenko

    Kharkiv Medical University.


Abstract

On the model of chronic aseptic carrageenan-induced inflam- mation in rats it is shown that low dose-rate y-radiation of small dose (0.1 Gy) leads to the increase of fibroblast and macrophage proliferation in the inflammatory focus, and pro- duces considerable decrease of lymphocyte emigration at all investigated radiation doses. Obtained data on stimulation of proliferation in the inflammatory focus with possible accumu- lation of DNA errors at depressed immunological supervision by lymphocytes can indirectly point to probability of oncog- enous potential increase in the chronic inflammatory focus at low dose-rate y-irradiation.

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