Bile acids in the processes of canalicular bileformation
T.B. Synelnyk, O.D. Synelnyk, V.K.Rybaltchenko
Institute of physiology of biology faculty of Taras ShevchenkoNational Kiev University
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Abstract
This review summarizes the current knowledge of the role of
bile acid in the canalicular bile secretion: its membrane transport
in hepatocyte; molecular mechanisms and pathways of
its regulatory effects on membrane transporters; the role of
its hydrophobicity in membrane transporter regulation; hepatocyte necrosis and apoptosis at cholestasis induced by
hydrophobic bile acids; the possible mechanisms of protective
effects of ursodeoxycholic acid in cholestatic imoairment of
the liver.
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