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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2003; 49(6): 22-30


Atp-sensitive K+channels and changes in their functional activities under streptozocin-induced diabetesmellitus

R.B.Strutinskii, O.O.Moybenko, S.N.Pyvovar, V.E.Dosenko, L.M.Yagupolskii

    A.A.Bogomoletz Institute of PhysiologyNational Academy of Science of Ukraine, Kiev


Abstract

Attenuation in the vasodilatory effects of a new synthesized opener of ATP-sensitive K+ channels on isolated aorta strips of rat has been shown under experimental (streptozocin-in- duced) diabetes mellitus. The level of that attenuation depen- ded on the nature of initial vasoconstriction. The most pro- nounced decrease - 43.34% as compared to the control res- ponses in healthy rats, we observed after norepinephrine- induced vasoconstriction. Following preliminary angiothensin- induced vasoconstriction and potassium depolarization, at- tenuation in vasoconstriction was 20.37 % and 22.4 %, res- pectively. Norepinephrine inhibited vasodilator effects of phlo- calin in the aorta of diabetic rats much more signiphicantly, as compared to those after potassium depolarization. Inhibitory effects of angiothensin II in rats with diabetes mellitus did not differ from those in the control rats. At the same time, con- strictory responses to biological active agents were preserved and they did not differ from those in control rats. We suggest that impairment in vascular reactivity under diabetes mellitus , at least in part, depends on the changes in the functioning of ATP-sensitive potassium channels.

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