Breathing regulation under intermittent hypoxic train-ing in patients with Parkinson’s disease
T.V.Serebrovskaya, E.E.Kolesnikova, I.N.Karaban
Bogomoletz Institute of Physiology, Kiev, Ukraine;Institute of Gerontology, Kiev, Ukraine
![](/images/cite.png)
Abstract
Ventilatory responses to hypoxic (HVR) and hypercapnic
(HCVR) stimuli in relation with dopamine (DA) and DAs
precursor dihydroxy phenylalanine (DOPA) venous blood
content were studied in healthy people aged 55-65 years (Gr.1)
and Parkinson’s disease (PD) patients without (Gr.2) and with
(Gr.3) L-DOPA treatment under intermittent hypoxic training
(IHT, three identical daily isocapnic, progressive, hypoxic rebreathing
sessions separated by 5-minute breaks for 14 consecutive
days). HVR in Gr. 2, when compared to Gr. 1, was
48% lower showing almost linear dependence and was accompanied
by lower levels of blood DOPA and DA content (26%
and 20%, respectively). HVR in Gr. 3 was only 17% lower
compared to Gr. 1 and was accompanied by higher levels of
blood DOPA and DA content (40% and 147%, respectively).
No differences in HCVR between groups were registered. IHT
produced a 75% increase in HVR in Gr.1 (p<0.05), 52% augmentation
of HVR in Gr.2 (p<0.05, at that the curves became
hyperbolic in shape), and 2.2-fold increase in Gr.3 (p<0.01).
The augmentation of hypoxic sensitivity under IHT was accompanied
by significant decrease in DOPA blood concentration
in Gr.1 and Gr.3, although no changes in Gr.2 were observed.
It was no changes in DA blood content in all groups.
IHT produced no significant changes in HCVR. This investigation
confirms the conception that PD is accompanied by
DA deficite not only in basal ganglia but also in peripheral
chemoreceptors provoking a decrease in hypoxic ventilatory
sensitivity. PD does not influence on hypercapnic sensitivity.
L-DOPA-treatment as well as IHT improve the functioning of
respiratory system, increase HVR and do not influence on
HCVR. The method of IHT can be involved in complex therapy of PD.
References
- Березовский В.А., Левашов М.И. Введение в оротерапию. – К., Изд – во Академии проблем гипорсии Российской Федерации, 2000. – 76 с.
- Колесникова Е.Э., Серебровская Т.В. Участие дофамина в процессах хеморецепции кислорода // Нейрофизиология – 1998. – 30, № 1. – С. 68 – 77.
- Колесникова Е.Э., Т.В. Серебровская. Возрастные особенности реакции системы дыхания на гипоксию и гиперкапнию и обмен катехоламинов приадаптации к периодической гипоксии // Архивклин. и эксперим. медицины. – 2001. – 10, №2. –C. 165 – 166.
- Лисенко Г.І., Т.В.Серебровська, І.М.Карабань, та ін. Використання методики поступово зростаючої нормобаричної гіпоксії у медичній практиці: Метод. рекомендації. – К., Вид-во МОЗ України, 1998. – 17 с.
- Оленев С.Н. Конструкция мозга. – М.: Медицина, 1987. – 208 с.
- Сиротин Н.Н. Эволюция резистентности и реактивности организма. – М.: Медицина, 1981. – 235 с.
- Ядгаров И.С., Николаенко Э.М. Особенности внешнего дыхания у пожилых больных паркинсонизмом // Геронтология и гериатрия: “Атеросклероз сосудов головного мозга и возраст”. – К., Вид-во МЗ Украины, 1971. – С. 360 – 363.
- Aaron E.A., Powell F.L. Effect of chronic hypoxia on hypobaric ventilatory responses in awake rats // J.Appl. Physiol. – 1993. – 74. – P. 1635 – 1640.
- 9. Bascom D.A., I.D.Clement, K.L.Dorrington et al. Effect of dopamine and domperidone on ventilation during isocapnic hypoxia in humans // Respir Physiol. – 1991. – 85. – P. 319 – 328.
- 10. Bee D., Pallot D.J. Acute hypoxic ventilation, carotid body cell division and dopamine content during early hypoxia in rats // J. Appl. Physiol. – 1995. – 79. – P. 1504 – 1511.
- Bernardi L., Passino C., Serebrovskaya Z. et al. Respiratory and cardiovascular adaptations tp progressive hypoxia. Effect of interval hypoxic training // Eur. Heart. J. – 2001. – 22. –P. 879 – 886.
- Bisgard G.E. Increase in carotid body sesnsitivity during sustained hypoxia // Biol. Signals. – 1995. – 4. – P. 292 – 297.
- Black A.M.S., Comroe J.H.Jr, Jacobs L. Species difference in carotid body response of cat and dog to dopamine and serotonine // Amer. J. Physiol. – 1972. – 233. – P. 1097 – 1102.
- Canning C.G., Alison J.A., Allen N.E. et al. Parkinson’s disease: an investigation of exercise capacity, respiratory function, and gait // Arch. Phys. Med. Rehabil. – 1997. – 78. – P. 199 – 207.
- Crowley T.J., Rutledge C.O., Hoehn M.M. et al. Low urinary dopamine and prediction of phenotiazine – induced Parkinsonism: a preliminary report // Amer. J. Psychiatry. – 1976. – 133. P. 703 – 706.
- Docherty R.J., McQueen D.S. Inhibitory action of dopamine on cat carotid chemoreceptors // J. Physiol. Lond. – 978. – 279. – P. 425 – 436.
- Eldrup E., Mogensen P., Jacobsen J. et al. CSF and plasma concentrations of free norepinephrine, dopamine, 3,4- ihydroxyphenilacetic acid (DOPAC), 3,4-dihydroxyphe-nilalanine (DOPA), and epinephrine in Parkinson’ disease // Acta Neurologica Scandinavica. – 1995. – 92. – P. 116 – 121.
- Engwall M.J.A., Bisgard G.E. Ventilatory responses to chemoreceptor stimulation after hypoxic acclimatization // J.Appl. Physiol. – 1990. – 69. – P. 1236 – 1243.
- 19. Fidone S., Gonzalez C., Yoshizaki R. Effects of low oxygen on the release of dopamine from the rabbit carotid body in vitro // J. Physiol. – 1982. – 333. – P. 93 – 110.
- 20. Gonzalez-Guerrero P.R., Rigual R., Gonzalez C. Effect of chronic hypoxia on opioid peptide and catecholamine levels and on the release of dopamine in the rabbit carotid body // J. Neurochem. – 1993. – 60. – P. 1769 – 1776.
- Gurvich H.E., Fainberg R.S. Increase of organism endurance to high – altitude flights. – In: Physiology and Hygiene of High-Altitude Flights / Ed. F.G.Krotkov. – Moscow-Leningrad, State publishing house of the biological and medical literature. – P. 109 – 118.
- Hoehn M.M., Crowley T.J., Rutledge C.O. Dopamine correlates of neurological and psychological status in untreated parkinsonism // J. Neurol. Neurosurg. Psychiat. – 1976. – 39. – P. 941 – 951.
- Ide T., Shirahata M., Chou C.L., Fitzgerald R.S. Effects of continious infusion of dopamine on the ventilatory and carotid body responses to hypoxia in cats // Clin. Exp.Pharmacol. Physiol. – 1995. – 22. – P. 658 – 664.
- Izquiredo – Alonso J.L., Jimenez – Jimenez F.J., Cabrera-Valdivia F. et al. Airway dysfunction in patients with Parkinson’s disease // Lung. – 1994. – 172. – P. 47 – 56.
- Jackobowith P.M., Richardson G.S. Method for the rapid determination of norepinephrine, dopamine and serotonine in the same brain region // Pharmacol. Biochem. Behaviour. – 1979. – 8. – P. 515 – 519.
- Kolchinskaya A.Z. Mechanisms of interval hypoxic training effects // Hypoxia Medical J. – 1993. – 1. – P. 5 – 7.
- Kolesnikova E.E., Serebrovskaya T.V. Age-related peculiarities of ventilatory responses to hypoxia and hypercapnia and of the catecholaminergic system under intermittent hypoxic training // J. Physiol. Pharmacol. (formerly Acta Physiologica Polonica). – 2002. – 53. – P.36.
- Matsumoto S., Kono M., Nakajima T. Effect of carotid body chemoreceptor stimulation on respiration and prenic nerve activity in intact and vagotomized rabbits // Arch. Int. Pharmacodyn. – 1981. – 252. – P. 298 – 306.
- 29. Mir A.K., McQueen D.S., Pallot D.J. et al. Direct biochemical and neuropharmacological identyfication of dopa- mine D2 – receptors in the rabbit carotid body // Brain. Res. –1984. – 291. – P. 273 – 283.
- 30. O’Halloran K. D., Janssen P.L., Bisgard G.E. Dopaminergic modulation of respiratory motor output in peripherally chemodenervated goats // J. Appl. Physiol. – 1998 – 85. – P. 946 – 954.
- Olanow C.W. Attempt to obtain neuroprotection in Parkinson’s disease // Neurology. – 1997. – 49, № 1 (Suppl. 1). – P. S26 – S33.
- Rosen J. M., Feinsilver S. H., Friedman J. H. Increased CO2 responsiveness in Parkinson’s disease: Evidence for a role of CNS dopamine in ventilatory control // Amer. Rev. Resp. Dis. – 1985. – 131. – P. A297.
- Sabate M., Gonzalez I., Ruperez F. et al. Obstructive and restrictive pulmonary dysfunction in Parkinson’s disease // J. Neurol. Sci. – 1996. – 138. – P. 114 – 119.
- Sabate M., Rodriguez M., Mendez E. et al. Obstructive and restrictive dysfunction increases disability in Parkinson’s disease // Arch. Phys. Med. Rehabil. – 1996. – 77. – P. 29 – 34.
- Sato M., Severighaus J.W., Bickler P. Time course of augmentation and depression of hypoxic ventilatory responses at altitude // J. Appl. Physiol. – 1994. – 77. – P. 313 – 316.
- Schamel A., Verna A. Localization of dopamine D2 receptor mRNA in the rabbit carotid body and petrosal ganglion by in situ hybridization // Adv. Exp. Med. Biol. – 1993. – 337. – P. 85 – 91.
- Serebrovskaya T.V., Ivashkevish A.A. Effects of one year exposure to altitudes on ventilatory responses to hypoxia and hypercapnia,metabolism and physical working capacity // J. Appl. Physiol. – 1992. – 73, № 5. – P. 1749 – 1755.
- Serebrovskaya T., Karaban I., Mankovskaya I. et al. Hypoxic ventilatory responses and gas exchange in patients with Parkinson’s disease // Respiration. – 1998. – 65, № 1. – P.28 – 32.
- 39. Serebrovskaya T.V., Karaban I.N., Kolesnikova E.E. et al. Geriatric men at altitudes: hypoxic ventilatory sensitivity and blood dopamine changes // Respiration. – 2000. – 67, № 3. – P. 253 – 260.
- 40. Serebrovskaya T.V., Karaban I.N., Kolesnikova E.E. et al. Human hypoxic ventilatory response with blood dopamine content under intermittent hypoxic training // Can. J. Physiol. Pharmacol. – 1999. – 77, № 12. – P. 967 – 973.
- Serebrovskaya TV. Intermittent Hypoxia Research in the Former Soviet Union and the Commonwealth of Independent States (CIS): History and Review of the Concept and Selected Applications // High Altitude Medicine Biology. – 2002. – 3, № 2. – P. 205 – 221.
- Solomon N.P., Hixon T.J. Speech breathing in Parkinson’s disease // J. Speech. Hear. Res. – 1993. – 36. – P. 294 – 310.
- Sun M.K., Spyer K.M. GABA-mediated inhibition of medullary vasomotor neurones by area posrema stimulation in rats // J. Physiol. (Lond. ). – 1991. – 436. – P. 669 – 684.
- Tatsumi K., C.K.Pickett, Weil J.V. Possible role of dopamine in ventilatory acclimatization to high altitude // Respir.Physiol. – 1995. – 99. – P. 63 – 73.
- Van der Kooy D., Koda L.Y. Organization of the projections of circumventricular organ: the area postrema in the rat // J. Comp. Neurol. – 1983. – 219. – P. 328 – 338.
- Vincken W.G., Gautier S.G., Dollfuss R.E. et al. Involvement of upper-airway muscles in extrapyramidal disorders. A cause of airflow limitation // N. Eng. J. Med. – 1984. – 311. – P. 438 – 442.
- Vrecko K., D. Storga,. Bikmayer J.G.D. et al. NADH stimulates endogenous dopamine biosynthesis by enhancing the recycling of tetrahydrobiopterin in rat phaeochromocytoma cells // Biochim. Biophys. Acta – Molecular Basis of Disease. – 1997. – 1361, №1. – P. 59 – 65.
- Wypych B., Szereda – Przestarzewska M. Depression of ventilation by dopamine in cats: effects of bilateral cervical sympathetic and vagal trunk section // Experimental Physiol. –1995. – 80. – P. 255 – 263.
|