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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2003; 49(3): 47-49


Influence of acute hypoxic hypoxia on nitric oxidesynthase induction in rats

A.G.Portnychenko, M.I.Vasylenko, A.A.Moybenko

    A.A.Bogomoletz Institute of Physiology, NAS of Ukraine, Kiev


Abstract

Male Wistar rats were exposed to acute normobaric hypoxia (10% O2) during 1 or 3 h. After 24 h iNOS protein expression was estimated in tissues by Western blotting. It was found, that iNOS protein expression was higher in heart right ventricles versus left ventricles in both control (intact) and hypoxic animals. Hypoxia caused marked time-depending iNOS induction in both heart ventricles and lungs but not significant in livers. These results suggest that iNOS-produced NO can play a role in response to acute hypoxia, acting at least on pulmonary circulation.

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