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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2003; 49(1): 100-103


The role of nitric oxide in meiotic maturation of the murine oocytes invitro

T.YU. Voznesenska, T.V.blashkiv

    Ін-т фізіології ім.О.О.Богомольця НАНУкраїни,Київ


Abstract

The preimplantation period is known to be critical for the normal murine development. Although the importance of nitric oxide during gestation was demonstrated, its role in the meiotic maturation of oocytes has not been defined yet. Effects of NO donor SNP and an inhibitor of nitric oxide synthase (NOS) L-NMMA on the meiotic maturation of the murine oocytes were studied in experiments in vitro. The results have shown that an activity of NOS in an oocyte was necessary for meiotic maturation; NO influenced the process of resumption of the oocyte maturation. Those results evidence that NO is a key modulator of the oocyte meiotic maturation in vitro.

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