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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2002; 48(6): 37-40


Low-conductance cationic channels in intact endothelium of rat aorta

S. M. Marchenko

    А.А.Bogomoletz Institute of PhysiologyNational Academy of Sciences of Ukraine, Kiev



Abstract

A new low-conductance cationic channel has been recorded with the patch-clamp technique in excised patches of the luminal membrane of intact endothelial cells. The channel had conductance of 5.4 pS and the lifetime of 46 ms. It was equally permeable for Na+ and K+, but impermeable to Cl-. The lifetime and probability of the open state of the channel were independent of the membrane potential.

References

  1. Яроцький В.В., Сагач В.Ф., Марченко С.М. Електричні властивості інтактного ендотелію аорти кроля // Фізіол.журн. – 2001. – 47, № 1. – С. 9 – 16.
  2. Яроцький В.В., Сагач В.Ф., Марченко С.М. Вплив циклічних нуклеотидів на мембранний потенціал інтактного ендотелію ізольованої аорти кроля //Там само. – 2001. – № 6. – С. 3 – 9.
  3. Beny J.L., Pacicca C. Bidirectional electrical communication between smooth muscle, endothelial cells in the pig coronary artery // Amer. J. Physiol. – 1994. – 266. –P. H1465 – H1472.
  4. Marchenko, S.M., Sage, S.O. Electrical properties of resting and acetylcholine-stimulated endothelium in intact rat aorta // J. Physiol. – 1993. – 462. – P. 735 – 751.
  5. Marchenko, S.M., Sage, S.O. Mechanism of acetylcholine action on membrane potential of endothelium of intact rat aorta // Amer. J. Physiol. – 1994. – 266 – P. H2388 – H2395.
  6. Marchenko, S.M., Sage, S.O. Calcium-activated potassium channels in the endothelium of intact rat aorta // J.Physiol. – 1996. – 492. – P. 53 – 60.
  7. Marchenko, S.M., Sage, S.O. Smooth muscle cells affect endothelial membrane potential in rat aorta // Amer. J. Physiol. – 1994. – 267. – P. H804 – H811.
  8. Marchenko, S.M. Sage, S.O. A novel mechanosensitive cationic channel from the endothelium of rat aorta // J.Physiol. – 1997. – 498. – Р. 419 – 425.
  9. 9. Nilius B., Droogmans G. Ion channels and Their Functional Role in vascular endothelium // Pysiol. Rev. – 2001. – 81, №4. – P. 1415 – 1459.
  10. 10. Usachev Y.M., Marchenko S.M., Sage S.O. Cytosolic calcium concentration in resting and stimulated endothelium of excised intact rat aorta // J. Physiol. – 1995. – 489. – P. 309 – 317.
  11. Yamamoto Y., Imaeda K., Suzuki H. Endothelium-dependent hyperpolarization, intercellular electrical coupling in guinea-pig mesenteric arterioles // J. Physiol. – 1999. –514. – P. 505 – 513.

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.