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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2002; 48(6): 31-36


Action of ang ii type 1 receptor inhibitor irbezartane on oxidative metabolism oflipids at essential hypertension

E.P. Svyshchenko, A.V. Kotsuruba, O.F. Meged, O.M. Buchanevich, V.V. Radchenko, N.M.Gulaya

    1M.D.Strazhesko Institute of cardiology Academy of medicalScience of Ukraine;2A.V.Palladin Institute of biochemistry National Academy ofScience of Ukraine, Kiev


Abstract

We evaluated the alters in plasma vasoconstriction eicosanoids (LTC4, TXB2) and diene conjugates (DC) levels in patients with essential hypertension (EH) after chronic (30 days, 235 mg per day) of irbezartane (inhibitor of ANG II type1 receptor with prolongation action «Aprovel» from «Sanofi») oral administration. Patients with EH have significantly higher plasma both LTC4, TXB2 and DC levels then healthy controls. This imbalance can be beneficially modulated by chronic irbezartane («Aprovel») administration. It is concluded that ANG II type 1 receptors can be involved in regulation of free arachidonic acid oxidation.

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