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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2002; 48(5): 79-92

HEME OXYGENASE AND CARBON MONOXIDE: THE PROTECTION OR THE INJURY OF THE CELLS?

T.V.Kukoba, A.A.Moibenko

    A.A.Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiуv.



Abstract

Heme oxygenase (HO) catalyzes the conversion of heme to carbon monoxide, iron, and biliverdin, which is immediately reduced to bilirubin. Three HO active isozymes exist: HO-1, an inducible heat shock protein (HSP32), and HO-2 and HO-3, which are constitutive and highly concentrated in neurons, spleen and liver. Heme oxygenase-1 is an inducible enzyme that catalyzes heme degradation and has been proposed to play a role in protecting cells against oxidative stress-related injury. The mechanism(s) of protection is not completely elucidated, although it is suggested that one or more of the catalytic by-products provide antioxidant functions either directly or indirectly. The role played by heme oxygenase in tissue pathology is determined by a delicate balance between the injurious and protective actions of heme, bilirubin, CO, and Fe2+. Autors review the functional role of HO and its derivates in cells biology and its real potential application to pathological conditions.

Keywords: HEME OXYGENASE, CARBON MONOXIDE, PROTECTION OR THE INJURY

Full text: (PDF, in Ukrainian)

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