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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

(English title: Physiological Journal)

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2025; 71(4): 104-116

Study and treatment of brain ischemic-reperfusion injury

S.V. Konovalov1, V.M. Moroz1, M.V. Yoltukhivskyy1, I.V. Gusakova1

  1. Vinnytsia National Pirogov Memorial Medical University
DOI: https://doi.org/10.15407/fz71.04.104


Abstract

Ischemic stroke, caused by impaired blood flow to the brain, remains one of the medical conditions associated with high mortality and long-term disability. Ischemia followed by recanalization of the occluded vessel (via thrombolysis or thrombectomy) triggers a cascade of biochemical events in the affected brain regions, resulting in ischemia-reperfusion injury and neuronal death. Conventional treatment of ischemic stroke, involving the use of antithrombotic and neuroprotective agents, is not always sufficiently effective or safe. Regenerative medicine, particularly stem cell transplantation, has emerged as a promising therapeutic approach for cerebral ischemia-reperfusion injury. Numerous experimental studies, along with some clinical trials, have investigated various types of stem cells. Stem cell–based therapy holds the potential to develop more effective and comprehensive strategies targeting neuroregeneration in the ischemia-damaged brain. This review aims to provide an updated perspective on acute cerebral ischemia-reperfusion, with particular emphasis on the underlying pathogenesis and morphological changes in both the ischemic core and penumbra, as well as the therapeutic prospects of stem cell–based interventions for cerebroprotection in acute ischemic stroke.

Keywords: brain ischemia-reperfusion; pathogenesis; morphological changes; mesenchymal stromal cells

Full text: (PDF, in English)

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