Helicobacter pylori is considered one of the possible risk factors for the development of digestive system pathology in general and pancreatic cancer in particular. The aim of the work was to investigate the pathogenetic relationship between helicobacteriosis and the risk of pancreatic cancer. The study was based on the results of an examination of 64 people aged 43-83 years, who were divided into two groups: the first group (comparison group, n = 34) – men and women without gastrointestinal pathology at the time of examination and the second group (main group, n = 30) – patients with unresectable, metastatic pancreatic head cancer, stage IV T1-4N0-2M1, complicated by obstructive jaundice. It was found that alcohol consumption in an amount of ≥150 g/week significantly increases the relative risk of developing pancreatic cancer by 2.3 (4.7; 1.5) times, and the presence of type II diabetes mellitus - by 2.5 (5.5; 1.6) times. When screening patients for Helicobacter pylori, the results of the rapid test were positive in the main group in 86.7% of patients, in the comparison group – in 73.5% of patients. Comparison of the results of serological examination revealed a significant difference in the content of immunoglobulin A to Helicobacter pylori in the studied groups, a positive test result was observed in 90% of patients in the main group and in 58.8% of patients in the comparison group. The content of immunoglobulin A to Helicobacter pylori in serum >19 U/ml can be considered as a probable risk factor for pancreatic cancer in patients who consume alcohol ≥150 g/week (sensitivity 85.7%, specificity 50%), or have type II diabetes (sensitivity 85.7%, specificity 53.9%).