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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

(English title: Physiological Journal)

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2025; 71(4): 58-65

THE ROLE OF THE PERIPHERAL SEROTONIN SYSTEM IN THE DEVELOPMENT OF GLUTAMATE-INDUCED OBESITY IN RATS AND ITS CORRECTION BY NANOCRYSTALLINE CERIUM DIOXIDE

M.M. Kondro1, T.I. Halenova2, O.M. Savchuk2, B.M. Vervega1, M.Ya. Spivak3

  1. Danylo Halytsky Lviv National Medical University
  2. Taras Shevchenko National University by Kyiv
  3. D. K. Zabolotny Institute of Microbiology and Virology National Academy of Sciences of Ukraine; Kyiv;
DOI: https://doi.org/10.15407/fz71.04.058


Abstract

Peripheral serotonin is an endocrine regulator of lipid metabo- lism, as demonstrated in studies on animals with diet-induced obesity and in observations of obese humans. However, data on its role in glutamate-induced obesity (GIO) are lacking in the literature. Therefore, the aim of our work was to study the functioning of the serotonin system in the blood serum and duodenal homogenate of rats with GIO, both with and without treatment with nanocrystalline cerium dioxide (nCeO₂). The study was carried out on 30 male white rats divided into three groups: intact, monosodium glutamate (MSG), and MSG + nCeO₂. Obesity was induced in the MSG and MSG + nCeO₂ groups via neonatal subcutaneous administration of MSG at a dose of 4 mg/g (dissolved in water for injection, 8 ml/g) on postnatal days 2, 4, 6, 8, and 10. At one month of age, the MSG-treated rats were randomly divided into untreated or nCeO₂-treated groups. The MSG group received water (2.9 ml/kg, orally), while the MSG + nCeO₂ group received a 1 mM solution of nCeO₂ (1 mg/kg, orally). The treatment was administered over three months in two-week courses (one course per month). In rats with GIO, blood serum levels of serotonin and tryptophan were decreased, while monoamine oxidase (MAO) activity was elevated, contributing to the М.М. Кондро, Т.І. Галенова, О.М. Савчук, Б.М. Вервега, М.Я. Співак 64 reduction in serotonin levels. In the duodenal homogenate, serotonin content was increased and tryptophan content was decreased, accompanied by reduced activity of MAO, tryptophan hydroxylase, and indoleamine 2,3-dioxygenase; tryptophan decarboxylase activity did not differ significantly from controls. The course administration of nCeO₂ to MSG- treated rats had a beneficial effect on these indicators. In conclusion, the peripheral serotonin system is involved in the development of obesity regardless of its origin, and nCeO₂ shows potential as a basis for the development of therapeutic and prophylactic agents.

Keywords: monosodium glutamate, obesity, serotonin, tryptophan, monoamine oxidase, tryptophan hydroxylase, tryptophan decarboxylase, indoleamine-2,3-dihydrogenase activity

Full text: (PDF, in Ukrainian)

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