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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

(English title: Physiological Journal)

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2025; 71(3): 110-119

Effects of CAPN1 and CAST gene polymorphism on growth and reproductive characteristics in Bos taurus, L. as a model object

N.G. Puzik1, V.O. Babalian2, V.R. Dorofieieva3, L.V. Mitiohlo4, O.M. Fedota5

  1. Kharkiv National Medical University, Ukraine
  2. MNPE “City Clinical Мultiprofile Hospital No. 17” of Кharkiv city council, Ukraine
  3. СNPE of Kharkiv regional council “Regional Clinical Perinatal Center”, Ukraine
  4. SE “RF “Nyva” of the M.V. Zubts IABG of NAAS”, Cherkasy region
  5. LLC “AMS”, Kharkiv, Ukraine
DOI: https://doi.org/10.15407/fz71.03.110


Abstract

The study aimed to analyze the effect of individual genotypes and allelic variants of the polymorphisms CAPN316 and CAST282 in calpain and calpastatin genes on the reproductive function of Aberdeen-Angus cows estimated by progeny growth traits. The growth dynamics of calves were assessed based on body weight at birth and the ages of 7, 8, 12, 15, and 18 months. The effect of polymorphic variants CAPN316 and CAST282 on the body weight of calves corresponds to the pattern of CC>GG>CG and CC>CG>GG genotypes of mothers. The effect of the G-allele for SNP CAST282 of the mother's genotype on the birth weight of male calves was +0.4±0.2 kg or +9%. By 12 months of age, the effect of maternal age in calves of different sexes tended to: young cows gave birth to heavier male calves (-23%), while heavier female calves were born to older cows (+27%). A 12–20% increase in newborn and weaning BW was associated with a one-day increase in calving interval. The F(ST) inbreeding coefficient in the studied sample for the CAPN316 and CAST282 polymorphisms was 11.8% and 7.5%, respectively. There was a negative correlation between the CAPN316 F(ST) inbreeding coefficient and the body weight of male calves at 12 and 15 months of age: r = -0.70 and r = -0.87. The positive effect of the spring–summer season on the body weight of calves at birth and up to 7 months was demonstrated, with calves born in the summer exhibiting higher average daily weight gains of +10% for males.

Keywords: calpain and calpastatin genes, CAPN316, CAST282, SNP, body weight, Aberdeen Angus breed.

Full text: (PDF, in English)

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