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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

(English title: Physiological Journal)

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2025; 71(3): 97-100

CONTRACTILE ACTIVITY OF ISOLATED PREPARATIONS OF THE RAT LIVER PORTAL VEIN UNDER THE ACTION OF ACETYLCHOLINE AND L-ARGININE

O.M. Pasichnichenko, P.I. Yanchuk, M.Yu. Makarchuk

  1. Taras Shevchenko National University of Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz71.03.097


Abstract

In acute experiments on rats, using the strain gauge method, the effect of acetylcholine and L-arginine on the smooth muscles of isolated preparations of the portal vein (PV) of the rat liver were investigated. Acetylcholine (1х10(-4) M and L-arginine (5.6х10(-4) M caused contraction of PV with intact endothelium. Deendothelization of the preparations by saponin (1 mg/ ml) led to decrease in the amplitude of contraction under the influence of the studied substances. The results obtained indicate an endothelium-dependent contraction of PV under the influence of acetylcholine and L-arginine, as well as the probable involvement of nitric oxide transformation products of endothelial origin in inducing such reaction.

Keywords: acetylcholine; L-arginine; portal vein; endothelium; nitric oxide.

Full text: (PDF, in Ukrainian)

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