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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

(English title: Physiological Journal)

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2025; 71(2): 93-105

Potential prognostic markers of cellular senescence in age-associated cardiovascular pathology

V. Kyryk1,2, O. Parkhomenko1

  1. M. D. Strazhesko National Scientific Center of Cardiology, Clinical and Regenerative Medicine, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
  2. D. F. Chebotarev State Institute of Gerontology, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz71.02.093


Abstract

The review addresses the issue of cellular senescence, its impact on the development of age-associated cardiovascular diseases, and its prognostic perspective. We appreciated the relationship between cellular senescence and overall organismal aging, focusing on endothelial dysfunction in cardiac patients. The review also discusses the manifestations of cellular aging and highlights their markers that can be used for comprehensive diagnosis and prediction of the risk of acute cardiovascular events. The potential and limitations of senolytic therapy for eliminating senescent cells and reducing systemic inflammation are discussed. The review emphasizes the importance of developing new methods for identifying markers of cellular senescence and implementing personalized approaches in the treatment of age-associated cardio- vascular diseases within the framework of modern precision medicine.

Keywords: cellular senescence; aging; cardiovascular diseases; endothelial dysfunction; senolytics

Full text: (PDF, in English)

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