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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2002; 48(5): 28-33

THE ACTION OF [CA2+] REGULATING AGENTS ON THE BILIARY SECRETION OF ADENYL NUCLEOTIDES

S.V. Tukaev, S.P. Veselsky, E.N. Reshetnik, P.S. Lyashchenko

    Research Institute of Physiology of Taras Schevchenko Kyiv National University,Kiev, Ukraine



Abstract

Many types of cells release ATP under the action of specific physiological signals. It is known that the ATP and other adenyl nucleotides is involved in the regulation of bile secretion too. The aim of our experiments was to determinate the influence of noradrenaline, fMLP and verapamile on the biliary secretion of adenyl nucleotides in bile-fistula rats. The biliary secretion of adenyl nucleotides was decreased under the influence of noradrenaline, fMLP (in doses 0,1 mkg/(100 g*30 min) and 10,0 mkg/(100 g*30 min)), verapamile and successive intraportal infusion of verapamile and noradrenaline (in 90 mM/l CaCl2 solution). It seems to be possible that noradrenaline, fMLP and verapamile regulate bile secretion on the level of energetic exchange.

Keywords: calcium, secretion, adenyl nucleotides

Full text: (PDF, in Ukrainian)

References

  1. Авдонин П.В., Ткачук В.А. Рецепторы и внутриклеточный кальций. – М.: Наука, 1994. – 288 с.
  2. Масюк А.И. Молекулярная физиология образования желчи // Вестн. Рос. АМН. – 1996. –№ 1. – С. 17–21.
  3. Орлов С.Н., Покудина Н.И., Гулак П.В. Транспорт кальция в гепатоцитах: механизмы и их регуляция. – В кн.: Гепатоцит: Функциональнометаболические свойства -М.: Медицина, 1985 –С. 192-212.
  4. Саратиков А.С., Скакун Н.П. Желчеобразование и желчегонные средства – Томск: Изд-во томск.ун-та, 1991 –260 с.
  5. Сафронова М.Н., Гусев Н.Б., Матвеева Л.Н., Фейгина М.М. Природные азотсодержащие соединения. Низкомолекулярные азотсодержащие соединения. –В кн.: Практикум по биохимии –М.: Изд-во моск. ун-та, 1989 –С. 183-187.
  6. Тукаєв С.В., Весельський С.П., Масюк А.І. Секреторна функція печінки при дії норадреналіну // Вісн. Київ. ун-ту. Проблеми регуляції фізіологічних функцій. – 1998. – Вип. 3. – C. 22–24.
  7. Тукаєв С.В., Масюк А.І. Порівняльне дослідження дії верапамілу і фентоламіну на секрецію жовчі у щурів // Там само. – C. 25-27.
  8. Тукаєв С.В., Решетнік Є.М., Весельський С.П., Лященко П.С. Вплив блокатора кальцієвих каналів верапамілу на секрецію жовчі –В кн.: Актуал. проблеми гастроентерології – К., 2001 – С. 52.
  9. 9. Bouscarel B., Kroll S.D., Fromm H. Signal transduction and hepatocellular bile acid transport: cross talk between bile acids and second messengers// Gastroenterology. – 1999. – 117, № 2 –P. 433-452.
  10. 10. Boyer J.L., Nathanson M.H. Bile formation // Schiffs diseases of the liver / Ed. E.R. Schiff.,M.F. Sorrell, W.C. Maddrey. – Philadelphia, 1999. –P. 119-146.
  11. Dolgova E.N., Tukaev S.V., Veselsky S.P., Masyuk A.I. The effect of chemotactic peptide fMLP on the bile secretion // Гастробюллетень. –2000. –№ 1–2 – С. 30.
  12. Frimmer M., Ziegler K. The transport of bile acids in liver cells // Biochemica et Biophysica Acta. –1988. – 947, № 17. – P. 75–99.
  13. Kamiike W., Nakahara M., Nakao K. et al. Correlation between cellular ATP level and bile excretion in the rat liver // Transplantation. – 1985. –39, № 1. - P. 50-55.
  14. Kast C., Stieger B., Winterhalter K.H., Meier P.J. Hepatocellular transport of bile acids. Evidence for distinct subcellular localizations of electrogenic and ATP-dependent taurocholate transport in rat hepatocytes // J. Biol. Chem. – 1994. – 269, № 7. –P. 5179-5186.
  15. Meier P.J. Molecular mechanisms of hepatic bile salt transport from sinusoidal blood into bile //Amer. J. Physiol. (Gastrointest. Liver Physiol.32). – 1995. – 269, № 6, part 1. – P. G801–G812.
  16. Muller M., Jansen P.L.M. The secretory function of the liver: new aspects of hepatobiliary transport // J. Hepatology. – 1998. – 28. – P. 344-354.
  17. Nathanson M.H., Burgstahler A.D., Masyuk A., LaRusso N.F. Stimulation of ATP secretion in the liver by therapeutic bile acids // Biochem. J. –2001 – 358. – P. 1–5.
  18. Paumgartner G. Bile formation and cholestasis: molecular mechanisms and clinical implications // Progress in hepato-pharmacology. –1997. –2. –P. 9–17.
  19. 19. Pozzan T., Rizzuto R., Volpe P., Meldolesi J. Molecular and cellular physiology of intracellular calcium stores // Physiol. Rev. –1994. – 74, № 3. –P. 595-636.
  20. 20. Roman R.M., Schwiebert E.M., Feranchak A.P. et al. Hepatocellular ATP-binding cassette (ABC) proteins modulate volume-sensitive ATP release //Hepatology. –1997. – 26, № 4, part 2, Suppl. –P. 194A.
  21. Roman R.M., Fitz J.G. Emerging roles of purinergic signaling in gastrointestinal epithelial secretion and hepatobiliary function // Gastroenterology –1999. –116, № 4 –P. 964–979.
  22. Sippel C.J., Suchy F.J., Ananthanarayanan M., Perlmutter D.H. The rat liver ecto-ATPase is also a canalicular bile acid transport protein //J. Biol. Chem. –1993. –268, № 3. –P. 2083–2091.
  23. Sippel C.J., McCollum M. J., Perlmutter D.H.Bile acid transport by the rat liver canalicular bile acid transport/ecto-ATPase protein is dependent on ATP but not on its own ectoATPase activity // Ibid. – 1994. –269, № 4. –P. 2820––2826.
  24. Zsembery A., Thalhammer T., Graf J. Bile formation: a concerted action of membrane transporters in hepatocytes and cholangiocytes // News Physiol.Sci – 2000. – 15, February –P. 6–11.
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