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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2002; 48(5): 28-33


THE ACTION OF [CA2+] REGULATING AGENTS ON THE BILIARY SECRETION OF ADENYL NUCLEOTIDES

S.V. Tukaev, S.P. Veselsky, E.N. Reshetnik, P.S. Lyashchenko

    Research Institute of Physiology of Taras Schevchenko Kyiv National University,Kiev, Ukraine


Abstract

Many types of cells release ATP under the action of specific physiological signals. It is known that the ATP and other adenyl nucleotides is involved in the regulation of bile secretion too. The aim of our experiments was to determinate the influence of noradrenaline, fMLP and verapamile on the biliary secretion of adenyl nucleotides in bile-fistula rats. The biliary secretion of adenyl nucleotides was decreased under the influence of noradrenaline, fMLP (in doses 0,1 mkg/(100 g*30 min) and 10,0 mkg/(100 g*30 min)), verapamile and successive intraportal infusion of verapamile and noradrenaline (in 90 mM/l CaCl2 solution). It seems to be possible that noradrenaline, fMLP and verapamile regulate bile secretion on the level of energetic exchange.

Keywords: calcium, secretion, adenyl nucleotides

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