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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

(English title: Physiological Journal)

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2025; 71(2): 84-92

Disorders of the antioxidant defense system of the organism in periodontitis and the use of various types of removable prosthetic constructions

A.Ye. Demkovych, Y.I. Poliukhovych

  1. I. Horbachevsky Ternopil National Medical University, Ukraine
DOI: https://doi.org/10.15407/fz71.02.084


Abstract

In 20-70% of patients, inflammatory reactions of the mucous membrane and the periodontal complex are observed, associated with the use of removable dentures made of basic plastics. The aim of our research was to investigate the disruption of the antioxidant defense system in rats with experimental bacterial-immune periodontitis under the conditions of using acrylic and nylon bases of removable dentures. Experimental periodontitis was induced in experimental animals by injecting a suspension containing a mixture of micro- organisms (Staphylococcus aureus and Streptococcus hemolyticus) based on egg protein into the periodontal tissues. The state of the antioxidant system was assessed by the activity of enzymes such as superoxide dismutase, catalase, ceruloplasmin, glutathione peroxidase, glutathione reductase and reduced glutathione on the 30th day of the experiment both without and with different types of removable denture bases fixed in the oral cavity of experimental animals. In animals with experimental periodontitis and acrylic dentures, increased catalase, superoxide dismutase, ceruloplasmin activity, and decreased glutathione levels were found compared to rats with nylon dentures. The results show differences in the effects of different types of denture bases on the antioxidant defenses of the organism.

Keywords: periodontium; periodontitis; antioxidants; oxidative stress; lipid peroxidation; removable prosthetics; prosthesis base; acrylic prosthesis; nylon prosthesis

Full text: (PDF, in English)

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